Desmoplastic small round cell tumor of the peritoneum (DSRCTP) is a rare, frequently fatal tumor. This retrospective study, based on CIBMTR registry data, describes the largest reported cohort of DSRCTP patients who have undergone autologous stem cell transplant (ASCT). The probabilities of disease-free survival (DFS) at one year for patients in complete remission (CR) and not in CR were 75% (95% confidence interval: 48–94%) and 35% (15–59%), respectively. The probability of overall survival (OS) at three years was 57% (29–83%) and 28% (9–51%) for patients in CR and not in CR respectively. Median survival for the entire cohort was 31 months (36 months and 21 months for those in CR and not in CR respectively). Engraftment at 42 days was 97% (88–100%). Treatment-related mortality was low, with only one death in the first 100 days. ASCT is a tolerable approach in patients with DSRCTP, with the greatest benefit seen in those patients who obtain CR. For those not in CR, the median OS in this series is greater than previously reported (21 months versus 17 months), suggesting ASCT is useful in prolonging DFS and OS, even in patients with residual or persistent disease pre transplant.
bag V40 Gy reductions up to 25%. The largest reductions were seen with the online 3 mm PTV margin strategy where rectal and bladder V40 Gy was reduced by 48% and 53% respectively. Plan selection resulted in 20% and 25% reduction in rectal and bladder V40 Gy. Conclusion: ART solutions for cervix EBRT reduce PTV volumes and OAR doses. Daily online re-planning delivers the largest OAR dose reductions. A clinical study combining MRI-guided RT and daily online replanning will assess clinical benefit in implementing these ART strategies.
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