Breast cancer is really one from tumor with highest mortality in this country as well as in the word. For early detection of the loco-regional breast cancer and disease confirmation, many diagnostic procedures were recommended with aims to help in decision for surgery treatment. This comparative study reported data by clinical analyses, ultra-sonography, mammography and histological findings obtained after ex tempore biopsy, in 59 women with breast cancer aged from 16 to 69. The highest incidence of cancer was obtained in women over 61 years of age, although high rate of breast cancer was found in aging between 21 to 50 years. The fibroadenoma were founded in 40.68%, while malignant carcinoma ductale in 13.55% of all cases. Correlation between applied analyses for fibroadenoma was found in 86.05% cases, while in malignant lesions this percentage was highest (93.33%). Apart of these methods applied for early diagnosis in general hospital and obtained statistical significance in diagnosis, new techniques based on molecular level (hormone receptor status) must be used.
Introduction: This study aimed to determine the role of the neutrophil to lymphocyte ratio (NLR) as a prognostic marker for patients with colorectal cancer (CRC) undergoing curative resection. Management of CRC and postsurgical treatment is usually arranged using the TNM staging system, but there are still prognostic variations among patients at the same TNM stage. Recent studies showed correlations between the inflammatory response and clinical outcomes in various cancers. The NLR reflected a systematic inflammatory response with some evidence suggesting that an elevated preoperative NLR is associated with poorer survival in patients with CRC. Methods: One hundred seventy eight patients with CRC, undergoing surgical resection in Surgical Departement Generaly Hospital Studenica Kraljevo-Serbia, between 2010. and 2015. were included in our retrospective analysis. Patients separated into two groups according to a cut-off value for NLR. Patient data included age, gender, localisation and differentiation of tumor, TNM stage, survival rate were analyzed for correlation with the NLR. Results: Using ROC curve analysis, we determined a cut-off NLR value of 2.1 in order to best detect differences in patient survival between our groups. The average length of survival in patients that had NLR 2.1 was 7.3 months (72.7612) and within these patients, the median of survival had not been reached. Patients with NLR > 2.1 had an average length of survival of 60 months (60.1163.4) and median of survival was 70.0. The log-rank test showed that there was a statistically significant difference (P ¼ .041) of survival between patients that had NLR 2.1 compared with those who had NLR > 2.1. Also, the log-rank test showed that advanced pathologic TNM stage (P ¼ .000), pathologic nodal stage (P ¼ .007) were predictive of shorter survival. Conclusion: High pre-treatment levels of NLR is a significant independent predictor of shorter survival in patients with colorectal cancer. This parameter is a simple, cheap, easily accessible laboratory value for identifying patients with poorer prognosis. P À 079 Circulating tumor cell detection and microsatellite instability status in predicting outcomes of advanced CRC patients
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