Highlights d Atomic models show CVA16 can simultaneously bind three distinct potent nAbs d The neutralization sites vary across three forms of CVA16 d CVA16 mature virion bearing conserved epitopes is the optimal vaccine immunogen d nAb-based assay allows quantification of mature virions for vaccine development

Excited states in the N ¼ 102 isotones 166 Gd and 164 Sm have been observed following isomeric decay for the first time at RIBF, RIKEN. The half-lives of the isomeric states have been measured to be 950(60) and 600(140) ns for 166 Gd and 164 Sm, respectively. Based on the decay patterns and potential energy surface calculations, including β 6 deformation, a spin and parity of 6 − has been assigned to the isomeric states in both nuclei. Collective observables are discussed in light of the systematics of the region, giving insight into nuclear shape evolution. The decrease in the ground-band energies of 166 Gd and 164 Sm (N ¼ 102) compared to 164 Gd and 162 Sm (N ¼ 100), respectively, presents evidence for the predicted deformed shell closure at N ¼ 100. In the exploration of the nuclear landscape, it is evident that the neutron-rich side of stability contains a vast unknown territory, where approximately half of all the bound nuclides remain to be identified. Furthermore, this is the domain of rapid-neutron-capture (r process) nucleosynthesis, which is poorly understood and yet is key to the creation of chemical elements from iron to uranium (Z ¼ 26-92) in stellar environments [1]. With the advent of the current generation of radioactive-beam facilities, it is now possible to address some of the open questions PRL 113, 262502 (2014) P H Y S I C A L

The level structure of the neutron-rich 77 Cu nucleus is investigated through β-delayed γ-ray spectroscopy at the Radioactive Isotope Beam Factory of the RIKEN Nishina Center. Ions of 77 Ni are produced by inflight fission, separated and identified in the BigRIPS fragment separator, and implanted in the WAS3ABi silicon detector array, surrounded by Ge cluster detectors of the EURICA array. A large number of excited states in 77 Cu are identified for the first time by correlating γ rays with the β decay of 77 Ni, and a level scheme is constructed by utilizing their coincidence relationships. The good agreement between large-scale Monte Carlo shell model calculations and experimental results allows for the evaluation of the singleparticle structure near 78 Ni and suggests a single-particle nature for both the 5=2 − 1 and 3=2 The evolution of the shell structure is one of the key motivations to study atomic nuclei with large neutron excess. The goal is to understand effects due to this excess of neutrons that are responsible for deviations from the conventional harmonic oscillator description with a strong attractive spin-orbit coupling, which characterizes the shell structure and properties of nuclei near the line of β stability. Such deviations are related to the monopole components of the effective nucleon-nucleon interaction and their strong effects on the single-particle energies (SPEs). The spindependent central component influences the energies of all single-particle orbitals, while the tensor interaction alters the spin-orbit splitting when specific orbits are filled by neutrons or protons [1][2][3][4][5][6][7][8].For the chain of Ni (Z ¼ 28) isotopes between N ¼ 40 and N ¼ 50, theoretical models predict significant changes in the proton SPEs as the ν1g 9=2 shell is filled by neutrons [3,4,[9][10][11][12]. Here, the tensor force responsible for SPE shifts

Abstract. Neutron-rich 160,161,162 Sm isotopes have been populated at the RIBF, RIKEN via β decay for the first time. β-coincident γ rays were observed in all three isotopes including γ rays from the isomeric decay of 160

Catecholamines play an important role in the development of cardiac hypertrophy. To observe cardiomyocyte-specific gene expression changes induced by catecholamines in vivo, left ventricular cardiomyocytes were isolated from male Sprague-Dawley rats after continuous infusion of norepinephrine (NE; 0.2 mg/kg per hour intravenously) for 0.5, 1, 2, 3 and 7 days. The gene expression profiles of these cells during different NE infusion stages were assessed by using a cDNA microarray, and the microarray data were further analyzed by a clustering method. Cardiac hypertrophy was induced upon continuous NE infusion, with the peak at 3 days. Meanwhile, manifest changes in gene expression profile within cardiomyocytes over the time course were revealed, most of the genes never having been reported to be involved in cardiac hypertrophy. The number of genes displaying differential expression also peaked at the middle stage of infusion (2-3 days), and the majority of the signaling molecules were found differentially expressed mainly at this stage, including phosphatidylinositol 3-kinase, calcium/calmodulin-dependent protein kinase II and non-receptor tyrosine kinases, etc. The tumor suppressor p53 was found up-regulated at very early (0.5 days) and late stages (7 days) of NE infusion. Self-organization clustering analysis revealed subsets of coordinate regulated genes. One set consisted of several enzymes involved in energy metabolism, including carnitine octanoyltransferase, ATP synthase subunit c, pancreatic lipase and glycogen phosphorylase, possessing a similar expression pattern with a rapidly elevated expression level at the early stage of NE infusion. This is the first study to provide transcriptional information for cardiomyocytes, a single cell type, in the heart during the development of cardiac hypertrophy in vivo, and may provide accurate clues to elaborate hypotheses about the evolution of this pathology.

Objective: To investigate the relation of trochlea morphology and patellofemoral alignment to prevalent radiographic patellofemoral osteoarthritis (PFOA). Design: A within-person knee-matched case-control study was performed. Participants with unilateral radiographic PFOA were selected from the Multicenter Population-based Osteoarthritis Study (MPOA) in three towns in northern China that was approved by Peking University Health Science Center Ethics Committee (2018PHB166-01). Radiographic PFOA, radiographic tibiofemoral OA, sulcus angle, patellofemoral index and patella displacement were assessed using posterio-anterior and skyline views of the knee. We classified sulcus angle, patellofemoral index and patella displacement into quarters and investigated the relation of each of these measures to prevalent radiographic PFOA. Results: Among 451 participants (mean age: 65.2 years, women: 66.8%) with unilateral radiographic PFOA, a reverse J-shaped relationship was observed between sulcus angle and prevalent radiographic PFOA (P ¼ 0.039 for quadratic term). Both higher patellofemoral index and patella displacement were associated with higher prevalent radiographic PFOA. Adjusted odds ratios (ORs) of prevalent radiographic PFOA in the highest quarter of patellofemoral index and patella displacement were 4.69 and 3.60 (P for trend <0.001), respectively, compared with the lowest quarter of each measurement. A similar relationship was observed between sulcus angle with either prevalent radiographic lateral or medial PFOA. Higher values of patellofemoral index and patella displacement were statistically significantly associated with higher prevalent radiographic lateral (ORs ¼ 5.07 and 4.59, respectively), but not medial PFOA (ORs ¼ 0.58 and 0.76, respectively). Conclusion: Extreme sulcus angles as well as higher values of patellofemoral index and patella displacement were associated with higher prevalent radiographic PFOA.

η photoproduction data on the proton up to E lab γ ≈2 GeV are interpreted within a chiral constituent quark formalism, which embodies all known three and four star resonances. This study confirms the need for a new S 11 resonance, with M=1.780 GeV and Γ=280 MeV, already introduced in investigating lower energy data.