The basic mechanisms of the course of bronchial asthma is initiated by the bronchospasm resulting from the liberation of histamine and other active substances; the release of biologically active substances is induced by the reaction of an antigen (allergen) which penetrates into the organism and the specific antibody formed against it, IgE (12). It is clear from a consideration of the very high number of foreign substances involved, together with the individual immune response (3) and bronchial activity (16), which vary with the age, that very many factors must he taken into account in the recognition and evaluation of the clinical picture. Many such relations have been put forward in the allergoiogical literature (9, II, 24, 25), but in most cases it is a matter of a supposed conclusion of general validity, deduced from a few, hut obvious connections. It therefore seemed necessary for us to try to estahlish the really essential, confirmahle relations from among the many factors affecting the condition of asthmatic children, by using principles of modern statistical evaluation (4, 6).
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