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CONDENSATIONIn women with twin pregnancies universal treatment with vaginal progesterone did not reduce the incidence of spontaneous birth between 24 +0 and 33 +6 weeks' gestation.
Short version of article title:Vaginal progesterone in unselected twin pregnancies.
AJOG AT A GLANCE• Randomized controlled trial testing the hypothesis that in women with twin pregnancies, vaginal progesterone at a dose of 600 mg per day from 11-14 until 34 weeks' gestation, as compared with placebo, would result in a significant reduction in the incidence of spontaneous preterm birth between 24 +0 and 33 +6 weeks.• In women with twin pregnancies universal treatment with vaginal progesterone did not reduce the incidence of spontaneous birth between 24+0 and 33+6 weeks' gestation. Post hoc time to event analysis led to the suggestion that progesterone may reduce the risk of spontaneous birth <32 weeks in women with cervical length <30 mm and it may increase the risk for those with cervical length ≥30 mm.• In women with twin pregnancies universal treatment with vaginal progesterone does not reduce the incidence of early spontaneous birth.
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