Lipoma is the most common soft tissue tumor, considered the universal tumor in the body. The differential diagnosis of a lipoma in the groin will include groin hernias, safina varex, lymphadenopathy, hydrocele and sarcoma. Due to the similarity of clinical symptoms and signs, the differentiation between inguinal, femoral hernias and groin lipoma is difficult. To avoid the high risk of intraoperative complications, correct diagnosis is an indication. We are reporting a case with huge lipoma arisen from the right groin mainly from right labium major of a 19-year-old single girl grown in a relatively short period to reach dimensions of a football and weighing 7200 grams. Painless, pedunculated tumor arose from labium major to the level of the knee, asymptomatic except unsightly huge mass, which treated successfully by surgical excision without complications and proved benign with no malignant changes detected.
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