The CARTaGENE (CaG) study is both a population-based biobank and the largest ongoing prospective health study of men and women in Quebec. In population-based cohorts, participants are not recruited for a particular disease but represent a random selection among the population, minimizing the need to correct for bias in measured phenotypes. CaG targeted the segment of the population that is most at risk of developing chronic disorders, that is 40-69 years of age, from four metropolitan areas in Quebec. Over 20,000 participants consented to visiting 1 of 12 assessment sites where detailed health and socio-demographic information, physiological measures and biological samples (blood, serum and urine) were captured for a total of 650 variables. Significant correlations of diseases and chronic conditions are observed across these regions, implicating complex interactions, some of which we describe for major chronic conditions. The CaG study is one of the few population-based cohorts in the world where blood is stored not only for DNA and protein based science but also for gene expression analyses, opening the door for multiple systems genomics approaches that identify genetic and environmental factors associated with disease-related quantitative traits. Interested researchers are encouraged to submit project proposals on the study website (www.cartagene.qc.ca).
Traditional estimation of sulcus size through limbal measurement is inadequate because limbus size alone cannot predict sulcus size. A general formula using the sphere and the mean corneal power can help predict sulcus size. Corneal power was significantly and negatively correlated with sulcus and limbus size as well as sphere. The standard error of sulcus measurement by UBM was 0.4 mm.
Background:
Urban green space may be important to mental health, but the association between long-term green space exposures and depression, anxiety, and cognitive function in adults remains unknown.
Methods:
We examined 8,144 adults enrolled in the CARTaGENE cohort in Quebec Canada. Average green space and change in green space with residential mobility were assessed using satellite-derived normalized difference vegetation index from 5-year residential address histories. Outcomes included depression and anxiety determined through medical record linkages, self-reported doctor diagnosis of depression, and the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7scales. Cognitive function was available for 6,658 individuals from computerized tests of reaction time, working memory, and executive function. We used linear and logistic multivariate models to assess associations between green space and each mental health and cognitive function measure.
Results:
In fully adjusted analyses, a 0.1 increase in residential normalized difference vegetation index within 500 m was associated with an odds ratio of 0.85 (95% CI: 0.76, 0.95) for a self-reported doctor diagnosis of depression and 0.81 (95% CI: 0.70, 0.93) for moderate anxiety assessed using the Generalized Anxiety Disorder 7 scale. Other models showed protective effects of urban green space on depression and anxiety but were not statistically significant, and the magnitude of association varied by green space exposure and mental health outcome assessment method. We did not observe any evidence of associations between green space and cognitive function.
Conclusions:
We observed some evidence to support the hypothesis that urban green space is associated with decreased depression and anxiety but not cognitive function.
Examiner bias was the greatest statistical bias in all sets of measures. Surgeons may want to opt for a "safe" limit of pupil size (ie, 0.5 to 0.8 mm greater than the measured size) when calculating optical zones in refractive surgery. Future devices for pupil measurement should be based on automatic adjustment sizing.
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