Introduction: Monosodium glutamate (MSG) is one of the most widely employed food enhancers. Although the umami compound, controversy persists regarding the effects of MSG intake on body weight. Chronic MSG intake may result in excessive body weight gain and obesity. Consumption of MSG result in organ damage, cardiovascular disease, oxidative stress, and also risk factors for obesity. This study aims to determine the effect of oral MSG on obesity in adult male Wistar rats (Rattus norvegicus).Methods: This true experimental study used the post-test control group design. Twenty-four adult male Wistar rats were randomly divided into four groups: control (received distilled water), Group 1 (MSG 0.378 mg/gr BW), Group 2 (0.756 mg/gr BW) and Group 3 (1.512 mg/gr BW). The obesity parameter was obtained by the Lee index. Kruskal-Wallis test follows by Mann-Whitney test were used to compare the Lee index between groups.Results: Lee’s index mean for each group was 358.4%, 314.1%, 287.8%, and 320.9%, respectively. The Kruskal Wallis test showed a significant difference in the Lee index between groups (p = 0.043). A follow-up test using Mann-Whitney found a significant difference between group 2 and the control group (p = 0.043, p <0.05). The mean of Lee index of group 2 was 70.51% lower than the control group.Conclusion: This study concluded that Lee index was not increased in MSG-treated rats than in the control group after oral MSG intervention for 21 days.
Purpose-The objective of this research is to know the correlation of stress level with the degree of depression in the elderly at a nursing home in Lhokseumawe in the year 2017. Design/Methodology/Approach-This research is analytic using a cross-sectional approach with a total sampling method. The total number of samples was 55 respondents. Findings-The results showed that the elderly in a Lhokseumawe nursing home at average are at mild stress level to medium degree of depression. Pearson correlation test results show that there is a correlation between stress level and degree of depression in elderly in the Lhokseumawe nursing home in 2017 with medium strong relationship (r 5 0.406; p 5 0.002). Research Limitations/Implications-We expect that the elderly living in the orphanage avoid negative thinking about themselves and the future, eliminating feelings of guilt or regret about past mistakes, taking adequate rest and maintaining a diet to avoid stress so as to prevent the onset of depression. Originality/Value-In addition the study increases the theoretical understanding of the correlation between stress level and degree of depression in elderly at nursing home.
Escherichia coli merupakan salah satu jenis utama bakteri Gram-negatif. Penyakit infeksi yang diakibatkan oleh bakteri Escherichia coli merupakan penyebab utama morbiditas dan mortalitas di dunia. Salah satu alternatif yang dapat dilakukan untuk mengatasi hal tersebut adalah dengan memanfaatkan senyawa yang terkandung dalam daun sukun. Daun sukun (Artocarpus altilis) mengandung senyawa seperti flavonoid, saponin, tanin, triterpen/steroid dan glikosida yang berfungsi sebagai antibakteri. Tujuan penelitian ini adalah untuk menguji apakah ekstrak etanol daun sukun (Artocarpus altilis) dapat mengahambat pertumbuhan bakteri Escherichia coli. Metode penelitian yang digunakan adalah metode posttest only control group design. Uji pengaruh ekstrak etanol daun sukun dilakukan dengan metode difusi dengan konsentrasi 10%, 20% dan 40% dengan kontrol positif amoxicillin dan kontrol negatif Dimethylsulfoxide (DMSO). Hasil penelitian ini didapatkan bahwa konsentrasi 10%, 20%, dan 40% menghasilkan rata-rata zona hambat sebesar 13,88 mm, 14,5 mm dan 14,3 mm. Data dianalisis menggunakan uji Kruskal-Wallis dengan p value 0,001 dan dilanjutkan dengan uji Mann-Whitney dengan adanya perbedaan yang bermakna p1 dan p2 (p : 0,035). Kesimpulan yang didapatkan dari penelitian ini adalah ekstrak etanol daun sukun (Artocarpus altilis) dengan konsentrasi 10%, 20%, dan 40% memiliki daya aktivitas antibakteri yang lemah terhadap Escherichia coli. Kata kunci : Antibakteri, ekstrak daun sukun, Escherichia coli
Introduction: Monosodium glutamate (MSG) is one of the most widely employed food enhancers. Although the umami compound, controversy persists regarding the effects of MSG intake on body weight. Chronic MSG intake may result in excessive body weight gain and obesity. Consumption of MSG result in organ damage, cardiovascular disease, oxidative stress, and also risk factors for obesity. This study aims to determine the effect of oral MSG on obesity in adult male Wistar rats (Rattus norvegicus).Methods: This true experimental study used the post-test control group design. Twenty-four adult male Wistar rats were randomly divided into four groups: control (received distilled water), Group 1 (MSG 0.378 mg/gr BW), Group 2 (0.756 mg/gr BW) and Group 3 (1.512 mg/gr BW). The obesity parameter was obtained by the Lee index. Kruskal-Wallis test follows by Mann-Whitney test were used to compare the Lee index between groups.Results: Lee’s index mean for each group was 358.4%, 314.1%, 287.8%, and 320.9%, respectively. The Kruskal Wallis test showed a significant difference in the Lee index between groups (p = 0.043). A follow-up test using Mann-Whitney found a significant difference between group 2 and the control group (p = 0.043, p <0.05). The mean of Lee index of group 2 was 70.51% lower than the control group.Conclusion: This study concluded that Lee index was not increased in MSG-treated rats than in the control group after oral MSG intervention for 21 days.
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