Objective. This study aims to evaluate the efficacy of various conventional synthetic DMARDs, including Tripterygium wilfordii Hook F (TwHF) for treating rheumatoid arthritis (RA) by network meta-analysis. Methods. We retrieved the related literature from online databases and supplemented it by using a manual retrieval method. Data was extracted from the literature and analyzed with STATA software. Results. A total of 21 trials (5,039 participants) were identified. Assessment of ACR20 response found that TwHF combined with methotrexate (MTX) had the greatest probability for being the best treatment option among the treatments involved, while TwHF used singly was second only to TwHF combined with MTX. Assessment of ACR50 response found that TwHF combined with MTX ranked second in all treatment options after cyclosporine A (CsA) combined with leflunomide (LEF) and TwHF alone, followed by TwHF combined with MTX. Assessment of ACR70 response found that CsA combined with LEF ranked first, TwHF combined with LEF ranked second, TwHF combined with MTX ranked third, and TwHF used singly ranked fourth. In the safety analysis, TwHF had the least probability of adverse event occurrence, followed by TwHF combined with MTX, which ranked first and second, respectively. Conclusion. Compared with the current csDMARDs for treating RA, the efficacy of TwHF was clear, and TwHF combined with MTX performed well under various endpoints. In the future, large, rigorous, and high-quality RCTs are still needed to confirm the benefits of TwHF therapy on RA.

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In this study, the T-matrix method combined with the addition theorems of spherical basis functions is applied to semi-analytically compute the underwater far-field acoustic scattering of a pair of rigid spheroids with arbitrary incident angles. The involvement of the addition theorems renders the multiple scattering fields of each spheroid to be translated into an identical origin. The accuracy and convergence property of the proposed method are verified and validated. The interference of specular reflection wave and Franz wave can be spotted from the oscillations of the form function. Furthermore, the propagation paths of specular reflection and Franz waves are quantitatively analyzed in the time domain with conclusions that the Franz waves reach the observation point subsequent to specular reflection waves and the time interval between these two wave series is equal to the time cost of the Franz waves traveling along the sphere surfaces. Finally, the effects of separation distances, aspect ratios (the ratio of the polar radius to equatorial radius), non-dimensional frequencies, and incidence angles of the plane wave on the far-field acoustic scattering of a pair of rigid spheroids are studied by the T-matrix method.