In high throughput settings we inspect a great many candidate variables (e.g., genes) searching for associations with a primary variable (e.g., a phenotype). High throughput hypothesis testing can be made difficult by the presence of systemic effects and other latent variables. It is well known that those variables alter the level of tests and induce correlations between tests. They also change the relative ordering of significance levels among hypotheses. Poor rankings lead to wasteful and ineffective follow-up studies. The problem becomes acute for latent variables that are correlated with the primary variable. We propose a two-stage analysis to counter the effects of latent variables on the ranking of hypotheses. Our method, called LEAPP, statistically isolates the latent variables from the primary one. In simulations, it gives better ordering of hypotheses than competing methods such as SVA and EIGENSTRAT. For an illustration, we turn to data from the AGEMAP study relating gene expression to age for 16 tissues in the mouse. LEAPP generates rankings with greater consistency across tissues than the rankings attained by the other methods.

Zero-Shot Hashing aims at learning a hashing model that is trained only by instances from seen categories but can generate well to those of unseen categories. Typically, it is achieved by utilizing a semantic embedding space to transfer knowledge from seen domain to unseen domain. Existing efforts mainly focus on single-modal retrieval task, especially Image-Based Image Retrieval (IBIR). However, as a highlighted research topic in the field of hashing, cross-modal retrieval is more common in real world applications. To address the Cross-Modal Zero-Shot Hashing (CMZSH) retrieval task, we propose a novel Attribute-Guided Network (AgNet), which can perform not only IBIR, but also Text-Based Image Retrieval (TBIR). In particular, AgNet aligns different modal data into a semantically rich attribute space, which bridges the gap caused by modality heterogeneity and zero-shot setting. We also design an effective strategy that exploits the attribute to guide the generation of hash codes for image and text within the same network. Extensive experimental results on three benchmark datasets (AwA, SUN, and ImageNet) demonstrate the superiority of AgNet on both cross-modal and single-modal zero-shot image retrieval tasks.

Empirical likelihood, Right censored data, Linear transformation models, Likelihood ratio test, Chi-squared distribution,

Through a detailed analysis of logs of activity for all Google employees 1 , this paper shows how the Google Docs suite (documents, spreadsheets and slides) enables and increases collaboration within Google. In particular, visualization and analysis of the evolution of Google's collaboration network show that new employees 2 , have started collaborating more quickly and with more people as usage of Docs has grown. Over the last two years, the percentage of new employees who collaborate on Docs per month has risen from 70% to 90% and the percentage who collaborate with more than two people has doubled from 35% to 70%. Moreover, the culture of collaboration has become more open, with public sharing within Google overtaking private sharing.

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