A concise total synthesis of lamellarins D (7 steps), H (7 steps), and R (5 steps) and ningalin B (5 steps) is achieved starting from the corresponding aldehydes and amines. The synthesis features three oxidative reactions as key steps in a biomimetic manner, involving an AgOAc-mediated oxidative coupling reaction to construct the pyrrole core, a Pb(OAc)(4)-induced oxidative cyclization to form the lactone, and Kita's oxidation reaction to form the pyrrole-arene C-C bond.

Pd doles it out: A palladium‐catalyzed approach to indoles using the title reaction was achieved (see scheme). The oxidant used in this catalytic cycle was O2. Both N‐nonsubstituted and N‐alkyl monosubstituted anilines can be successfully transformed into the corresponding indoles by this method.

Dual activation of CH bonds has enabled the preparation of polycyclic aromatics from arylindoles and arylbenzofurans in the absence of a directing group, and with using O2 as the oxidant (see scheme). Synthetically and medicinally important polycyclic aromatics have been easily prepared, and some of the resulting polycyclic heteroaromatics exhibit intense fluorescence.

Scheme 1. Hydroxylation of C sp 2ÀH bonds. BQ = benzoquinone, DG = directing group.

From simple beginnings: A novel Cu‐promoted direct incorporation of nitrogen into simple hydrocarbon molecules under mild and neutral reaction conditions is described. 1,5‐Disubstituted tetrazoles are efficiently constructed by two C sp 3H and one CC bond cleavages (see scheme; TMS=trimethylsilyl). This protocol provides a new and unique strategy to functionalize simple and readily available hydrocarbon molecules.

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Recent observations of the light component of the cosmic-ray spectrum have revealed unexpected features that motivate further and more precise measurements up to the highest energies. The Dark Matter Particle Explorer (DAMPE) is a satellite-based cosmic-ray experiment that is operational since December 2015, continuously collecting data on high-energy cosmic particles with very good statistics, energy resolution, and particle identification capabilities. In this work, the latest measurements of the energy spectrum of proton+helium in the energy range from 46 GeV to 316 TeV are presented. Among the most distinctive features of the spectrum, a spectral hardening at ∼600 GeV has been observed, along with a softening at ∼29 TeV measured with a 6.6σ significance. Moreover, by measuring the energy spectrum up to 316 TeV, a strong link is established between space-and ground-based experiments, also suggesting the presence of a second hardening at ∼150 TeV. * https://geant4.web.cern.ch/node/302 † https://web.ikp.kit.edu/rulrich/crmc.html

A novel and efficient copper or nickel catalyzed highly selective denitrogenative annulation of vinyl azides with aryl acetaldehydes has been developed. 2,4- and 3,4-diaryl substituted pyrroles, which are difficult to synthesize by the reported methods, can be highly regioselectively prepared by this protocol simply switched by the selection of the transition metal catalysts. Compared with the reported acidic or basic conditions for polysubstituted pyrrole synthesis, the present reaction conditions are mild, neutral, and very simple without any additives.