Abnormal tumor microenvironment (TME) facilitates tumor proliferation and metastasis and establishes physiological barriers for effective transport of therapeutics inside the tumor,posing great challenges for cancer treatment. We designed ac ore-satellite sizet ransformable nanoframework (denoted as T-PFRT) that can synchronously adapt to and remold TME for augmenting photodynamic therapyt o inhibit tumor growth and prevent tumor metastasis.U pon matrix metalloproteinase 2(MMP2)-responsive dissociation of the nanoframework in TME, the core structure loaded with TGFb signaling pathway inhibitor and oxygen-carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing photosensitizer-encapsulated satellite particles to penetrate to deep-seated tumor for oxygen-fueled photodynamic therapy. T-PFRTc ould overcome the stroma and hypoxia barriers for delivering therapeutics and gain excellent therapeutic outcomes in the treatment of primary and metastatic tumors.
Self-assembly
processes, while promising for enabling the fabrication
of complexly organized nanomaterials from nanoparticles, are often
limited in creating structures with multiscale order. These limitations
are due to difficulties in practically realizing the assembly processes
required to achieve such complex organizations. For a long time, a
hierarchical assembly attracted interest as a potentially powerful
approach. However, due to the experimental limitations, intermediate-level
structures are often heterogeneous in composition and structure, which
significantly impacts the formation of large-scale organizations.
Here, we introduce a two-stage assembly strategy: DNA origami frames
scaffold a coordination of nanoparticles into designed 3D nanoclusters,
and then these clusters are assembled into ordered lattices whose
types are determined by the clusters’ valence. Through modulating
the nanocluster architectures and intercluster bindings, we demonstrate
the successful formation of complexly organized nanoparticle crystals.
The presented two-stage assembly method provides a powerful fabrication
strategy for creating nanoparticle superlattices with prescribed unit
cells.
We report a DNA origami cipher disk (DOCD) allowing random, continuous and reversible switchover between six visibly different patterns in response to the input DNA strands. A DOCD-enabled tandem-in-time cryptographic...
Abnormal tumor microenvironment (TME) facilitates tumor proliferation and metastasis and establishes physiological barriers for effective transport of therapeutics inside the tumor,posing great challenges for cancer treatment. We designed ac ore-satellite sizet ransformable nanoframework (denoted as T-PFRT) that can synchronously adapt to and remold TME for augmenting photodynamic therapyt o inhibit tumor growth and prevent tumor metastasis.U pon matrix metalloproteinase 2(MMP2)-responsive dissociation of the nanoframework in TME, the core structure loaded with TGFb signaling pathway inhibitor and oxygen-carrying hemoglobin aims to stroma remodeling and hypoxia relief, allowing photosensitizer-encapsulated satellite particles to penetrate to deep-seated tumor for oxygen-fueled photodynamic therapy. T-PFRTc ould overcome the stroma and hypoxia barriers for delivering therapeutics and gain excellent therapeutic outcomes in the treatment of primary and metastatic tumors.
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