COPD patients with other than Danish ethnic background discontinued COPD maintenance therapy more often than ethnic Danes. Attention to the barriers of persistent COPD medication use in COPD patients from ethnic minorities should be payed to facilitate better COPD management.
Ethnicity was largely overlooked. Most studies neglected to report ADRs by ethnicity. Lack of consistency in defining ethnicities complicated further pooled analyses. Despite the higher prevalence of asthma among specific ethnic minority groups, few studies disaggregated information by ethnic background, and reports of ADRs to asthma medications in different ethnic groups were rare. We suggest that the inclusion of ADR analysis by different ethnic backgrounds is desirable.
The aim of this study was to investigate the differences in age at diagnosis and survival time after diagnosis between Chronic Obstructive Pulmonary Disease (COPD) patients with native Danish and other ethnic backgrounds. Individuals diagnosed with COPD in a hospital setting in Copenhagen in the period 2003-2007 were identified from annual hospital contact records. The cohort was restricted to COPD patients older than 35 years old at diagnosis. Follow-up was available until the end of 2010. ANOVA was conducted to test if mean age at diagnosis differed between the patient groups with different ethnicity. Kaplan-Meier estimator was used to estimate survival time after diagnosis. Cox proportional hazards models were conducted to calculate hazards of death according to ethnicity. A total of 2845 COPD patients were included; 131 (4.6%) were with non-Western ethnic minority backgrounds. Patients with non-Western ethnic backgrounds were diagnosed at a younger age and had a better survival probability compared to ethnic Danish patients; hazard ratio HR (95% CI) for death during follow-up in non-Western vs. ethnic Danish patients was 0.33 (0.18-0.62). Our study showed marked differences in age at diagnosis and survival time after diagnosis between the COPD patients with different ethnic backgrounds residing in Copenhagen. Further studies are needed to find out the reasons for younger age of COPD diagnosis in non-Western minorities and for shorter survival time after diagnosis in ethnic Danish COPD patients.
In the Acknowledgements section, the text at the end of the paragraph "and Helle Wallach-Kildemoes from the University of Copenhagen for the inputs during the manuscript preparation." should read "and Helle Wallach-Kildemoes from the University of Copenhagen for important methodological advice under the preparation of the study".
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