Recent studies have reported that coronavirus disease-2019 (COVID-19)
vaccination can exacerbate asthma. Status asthmaticus sometimes induces
takotsubo cardiomyopathy. We present a case of takotsubo cardiomyopathy
triggered by asthma exacerbation after the mRNA-based vaccination.
Therapies for status asthmaticus resulted in prompt improvement of
respiratory failure and cardiac-apex ballooning.
It is recommended to get the multiple coronavirus disease 2019 (COVID-19) vaccinations for almost all people including asthma patients. A 70-year-old Japanese woman with asthma experienced worsening of respiratory symptoms after the second dose of the mRNA-based COVID-19 vaccine BNT162b2. The patient had hypercapnic respiratory failure and cardiac-apex ballooning and was diagnosed with takotsubo cardiomyopathy induced by asthma exacerbation. Therapies for asthma exacerbation resulted in prompt improvement of respiratory failure and cardiac-apex ballooning. Our findings suggest that asthma patients are prone to exacerbations after receiving the COVID-19 vaccination; therefore, stratification of the patients at risk is required.
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