BackgroundThe wound healing process is complex and still poorly understood. Sericin is a silk protein synthesized by silk worms (Bombyx mori). The objective of this study was to evaluate in vivo wound healing effects of a sericin-containing gel formulation in an incision wound model in rats.Material/MethodsTwenty-eight Wistar-Albino rats were divided into 4 groups (n=7). No intervention or treatment was applied to the Intact control group. For other groups, a dorsal skin flap (9×3 cm) was drawn and pulled up with sharp dissection. The Sham operated group received no treatment. The Placebo group received placebo gel without sericin applied to the incision area once a day from day 0 to day 9. The Sericin Group 3 received 1% sericin gel applied to the incision area once a day from day 0 to day 9. Hematoxylin and eosin stain was applied for histological analysis and Mallory-Azan staining was applied for histoimmunochemical analysis of antibodies and iNOS (inducible nitric oxide synthase), and desmin was applied to paraffin sections of skin wound specimens. Parameters of oxidative stress were measured in the wound area.ResultsEpidermal thickness and vascularization were increased, and hair root degeneration, edema, cellular infiltration, collagen discoloration, and necrosis were decreased in Sericin group in comparison to the Placebo group and the Sham operated group. Malonyldialdehyde (MDA) levels were decreased, but superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities were increased in the sericin group.ConclusionsWe found that sericin had significant positive effects on wound healing and antioxidant activity. Sericin-based formulations can improve healing of incision wounds.
Owing to the advancements in medicine, new information is obtained regarding cancer, new antineoplastic agents are developed. Frequent use of these new pharmacological agents emergency physicians to be vigilant about their side effects. We present a case of adrenal crisis in a patient with non-small cell lung cancer (NSCLC), caused by an immunomodulatory drug; nivolumab. While adverse events are related to other immunomodulatory drugs have been reported in literature, our case is the first nivolumab-related adrenal failure to be reported. A patient with lung cancer presented to the emergency room(ER) with nausea and vomiting. Hyponatremia, hyperkalemia, persistent hypoglycemia led to the diagnosis of adrenal crisis. Having direct effect on the immune system, these drugs were claimed to be highly reliable. However, there is no reliable data on the side effect profile of these agents. It should be kept in mind that life-threatening auto-immune reactions may occur.
Social media, through the Internet and other web-based technologies, have become a means of communication and knowledge-sharing. In this article, we provide details about the social media traffic of various scientific activities, the organizations of which we have played an active role in. We also provide information in our native language through our FOAMed website, which has been published for about 30 months, with us acting as editors. We are comparing these local and limited ventures with examples from the world and aim to remind that social media sources play a very important role in sharing knowledge in medical training and encouraging local initiatives, like ours, with limited resources.
Most of the patients were young single women. Altered mental state and tachycardia were the commonest symptoms. The initial symptoms of amytriptyline overdose patients may be life threatening, but effective supportive treatments were helpful. There was high correlation between ADORA criteria and the dose ingested.
AmaçTravmatik el ve el bileği yaralanmaları acil serviste yaygın görülen yaralanmalardır. Ani öfkelenmeye bağlı cama yumruk atma ile ilişkili el ve el bileği yaralanmaları ülkemizde sıktır. Bu çalışmanın amacı oluş nedenlerine göre cam kesisi ile ilişkili el ve el bileği yaralanmalı hastalarda klinik ve demografik özellikleri analiz etmektir. Gereç ve Yöntem Dicle Üniversitesi Tıp Fakültesi Acil Servisi'ne cam kesisine bağlı yaralanma nedeniyle başvuran hastalar çalışmaya dahil edildi. Hastaların demografik verileri standart çalışma formuna kaydedildi. Demografik veriler istatistiksel olarak analiz edildi. BulgularÇalışmaya 154 hasta dahil edildi. Hastaların %53.8'I ani sinirlenmeye bağlı olarak cama yumruk atan hastalardı. Cama yumruk atma erkeklerde daha sık gözlendi (n=81, %97.6), yumruk atan grupta sağ el yaralanması daha sık görüldü (n=65, %78.3). Cama yumruk atma ile ilişkili yaralanmalı 24 hasta (%28.9) alkollüydü ve bu hastalarda radial arter, ulnar sinir, median sinir ve ulnar arter yaralanması anlamlı düzeyde yüksek bulundu. SonuçEl ve el bileği yaralanması nedeniyle acil servise başvuran hastaların damar, sinir ve tendon muayenelerinin dikkatli yapılması, özellikle alkollü hastalarda bu anatomik yapıların yaralanmalarının birlikte olabileceği, sonrasında ciddi fonksiyon kayıplarına yol açmaması için erken dönemde kontrollerinin yapılması sağlanmalıdır.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.