Background. Gastric cancer (GC), an extremely aggressive tumor with a very different prognosis, is the third leading cause of cancer-related mortality. We aimed to construct a ferroptosis-related prognostic model that can be distinguished prognostically. Methods. The gene expression and the clinical data of GC patients were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus database (GEO). The ferroptosis-related genes were obtained from the FerrDb. Using the “limma” R package and univariate Cox analysis, ferroptosis-related genes with differential expression and prognostic value were identified in the TCGA cohort. Last absolute shrinkage and selection operator (LASSO) Cox regression was applied to shrink ferroptosis-related predictors and construct a prognostic model. Functional enrichment, ESTIMATE algorithm, and single-sample gene set enrichment analysis (ssGSEA) were applied for exploring the potential mechanism. GC patients from the GEO cohort were used for validation. Results. An 8-gene prognostic model was constructed and stratified GC patients from TCGA and meta-GEO cohort into high-risk groups or low-risk groups. GC patients in high-risk groups have significantly poorer OS compared with those in low-risk groups. The risk score was identified as an independent predictor for OS. Functional analysis revealed that the risk score was mainly associated with the biological function of extracellular matrix (ECM) organization and tumor immunity. Conclusion. In conclusion, the ferroptosis-related model can be utilized for the clinical prognostic prediction in GC.
Creating
photoactive nanofibrous membranes for effective antibacterial
activity is highly desired for healthy living, yet it still remains
a great challenge. Herein, we present a scalable methodology to prepare
anthraquinone-2-carboxylic acid grafted silk fibroin/cellulose acetate
blend nanofibrous membranes (G-SF/CA BNM) by combining green biomass
materials and electrospinning, which could produce reactive oxygen
species (ROS) under UVA irradiation. The resultant G-SF/CA BNMs exhibited
integrated properties of ultrathin fiber diameter (154 nm), larger
surface area (11.25 m2 g–1), good mechanical
properties, robust photoactive activity, and high bactericidal efficiency
(99.9999% contact-killing). The fabrication of such fascinating materials
may provide new insights into the design and development of photoactive
nanofibrous membranes for antibacterial application.
Constructing
nanosized photoactive membrane materials would facilitate
the pretreatment of dyeing wastewater and reducing environmental pollution.
However, preparation of such membrane materials remains tremendously
challenging. In this work, we fabricate the silk-derived nanofibrous
membranes modified with 3,3′,4,4′-benzophenone tetracarboxylic
dianhydride (BDSNM) that could yield reactive oxygen species (ROS)
driven under UV light irradiation. The premise of this study is that
BDSNM can store photoactive activity at UV light and release ROS under
dark conditions. The resultant BDSNM exhibited extra-fine fiber diameter
(129 nm), larger surface area (13.8 m2 g–1), superhydrophilicity, fast ROS production, good activity storing
capacity, and good degradation capacity for reactive red 195 (>99.9999%)
within 30 min. The effective synthesis of such economic and fascinating
BDSNM may pave a way for fabrication of photoactive membranes for
dye degradation.
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