Медицинская академия им. С. И. Георгиевского Крымского федерального университета им. В. И. Вернадского, Симферополь, Россия 2 Первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский Университет), Россия influence of auTo-and Xenogenic fiBroBlasTes and dermal eQuiValenT on macroPhage conTenT in granulaTiVe Tissue of ishemic cuTaneus Wound on The 12 daY of regeneraTiVe hisTogenesis shapovalova e. Yu. 1 , demyashkin g. a. 2 , Boyko T. a. 1 , Baranovskiy Yu. g. 1 , morozova m. n. 1 , Baranovskiy a. g. 1 , ageeva e. s. 1 1 medical academy named by s. i. georgievsky of V. i. Vernadsky crimean federal university, simferopol, russia 2 i. m. sechenov first moscow medical university, russia
The problem of healing long-term skin defects, complicated by venous insufficiency, remains a problem despite many known treatments. The article researches immunological compatibility and efficiency of the use of collagen sponges with skin allogeneic fibroblasts for stimulation of wound healing. Sixteen mature C57/B1 mice were divided into two equal groups: control and experimental. In the 10th-day dynamic, the stimulation method was found to be highly effective by associating the collagen sponge with the allofibroblasts, which allows a significant improvement in the morphological characteristics of the sample biopsy and does not cause an autoimmune response to the transplant.
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