2-Oxo-2-polyfluoroalkylethane-1-sulfones and -sulfamides undergo Biginelli reaction with aryl aldehydes and (thio)urea to give 4-hydroxy-4-polyfluoroalkyl-5-sulfonyl-6-aryltetrahydropyrimidin-2(1H)-(thi)ones, whereas three-component reaction with urea and trialkyl orthoformate provides 4-hydroxy-4-polyfluoroalkyl-5-sulfonyl-3,4-dihydropyrimidin-2(1H)-ones. Some chemical properties of the synthesized pyrimidinones are discussed.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.