Changes are described that are brought about by antimycin, NoHOQnO, funicuiosin, myxothiazol and mucidin in the c+, /3-and y-absorption bands of reduced and oxidized cytochromes b in the isolated complex bc, form beef heart mitochondria. The inhibitors can be divided into 2 groups. Antimycin, funiculosin and NoHOQnO are likely to shift the spectrum of b-562 and compete for specific binding with complex bc,, with each other but not with myxothiazol and mucidin. The spectral effects of the latter two inhibitors are more difficult to interpret and may involve contributions not only from b-562 but from b-566 as well. The existence of 2 independent inhibitor binding-sites in the complex bc, corroborates the Q-cycle hypothesis.
Cytoehrome b Q cycleSpectral shifr
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