Ab initio electronic structure calculations and variational transition state theory are used to calculate reaction
energetics and rate constants for the gas-phase reactions of OH- with CH(4
-
n
)Cl
n
for n = 1−4. Two reaction
pathways are considered, second-order (bimolecular) nucleophilic substitution (SN2), and proton transfer.
Benchmark electronic structure calculations using CCSD(T) and basis sets as large as aug-cc-pVQZ are
performed to obtain highly accurate estimates of the enthalpies of reaction. These results are extrapolated to
the complete basis set limit for comparison with experiment and to establish the level of theory needed to
provide energies that are accurate to better than a few kJ/mol. Energies of critical geometries (reactant
complexes, saddle points, and product complexes) are computed for all systems. For the SN2 reaction, the
potential energy and its first and second derivatives along minimum energy paths are computed and used
directly in variational transition state theory (VTST) calculations of the rate constants. These calculations
indicate that for n = 1−3 the region of the potential in the asymptotic reactant channel controls the reaction
rate constants and that the loose-transition-state methods implemented in variflex provide the best estimates
of the reaction rate constants. The reaction with n = 4 has a dynamical bottleneck that lies near the saddle
point and is best treated using the VTST methods implemented in polyrate.
Photochemical properties of a series of bifunctional monosubstituted derivatives of cymantrene containing a C-, N-, or O-bound π-allyl group, along with n-donating carbamate, amide, or pyridine fragments were investigated. The results obtained demonstrate that the nature and thermodynamic stability of the cyclopentadienylmanganese dicarbonyl chelates derived from bifunctional monosubstituted cymantrene derivatives depend substantially on both the nature of the functional groups and on their position in the substituent at the Cp ring. Thus, for the six-membered chelates, the thermodynamic stability increases in the series carbamates < amides < pyridines < olefins. Some of the dicarbonyl chelates studied form reversible photochromic systems due to linkage isomerization between different donating groups of the bifunctional substituent and the manganese atom with a wide range of times of thermal isomerization.
This study utilizes ab initio calculations to investigate the reaction of high-temperature solid-state catalytic
isotope exchange (HSCIE) between amino acids and spillover tritium. The Hartree−Fock approximation and
second-order Møller−Plesset perturbation theory in conjunction with 6-31G* and aug-cc-pVDZ basis sets
were used to calculate potential energy surfaces for the interactions between CH4, alanine, hydroxyproline,
and the H3O+ ion. Ab initio calculations were used to estimate the activation energies and structures of the
transition states of these reactions. The hydrogen exchange reaction occurs by a synchronous mechanism,
with a transition state that is characterized by pentacoordinated carbon. The proposed one-center mechanism
is in good agreement with observed retention of configuration of the asymmetric carbon atoms in the HSCIE
reaction with spillover tritium in experiments. The regioselectivity and stereoselectivity of hydrogen isotope
exchange in amino acids with spillover tritium can be predicted on the basis of ab initio calculations of
interaction of this compound with a model acidic center, taking the H3O+ ion as an example.
Solid-state catalytic isotope exchange
of hydrogen under the action
of spillover hydrogen in organic compounds applied on a nonorganic
carrier has been studied. The deuterium-labeled peptide [D]dalargin
containing 14 deuterium atoms, [D]melatonin, and [D]histamine with
the 72–92% substitution degree of all C–H bonds were
prepared by this reaction. The activation energy of hydrogen isotope
exchange with T2 and D2 in glycine and α-aminoisobutyric
acid was obtained experimentally. It was shown that for the studied
reaction the kinetic isotopic effect is 1.2–1.4 by the Hartree–Fock
method, which is several times smaller than one in the liquid-phase
reactions. Quantum chemical calculations of the isotope shift values
in the electronic spectra of deuterium-labeled metal ion complexes
were performed using the RB3LYP/LanL2DZ and CIS/LanL2DZ methods for
calculation of the ground and the excited states. It was shown for
deuterium-labeled histamine complexes [D12]Pd(him)2Cl2 and [D12]Cu(him)2Cl that
the isotopic effect of UV spectra was 1600 and 1800 cal/mol, respectively.
The measurement of isotopic shifts for electronic transitions potentially
can be utilized as a new informative method for the investigation
of complex formation. The deuterium-labeled compounds were shown to
be useful as internal standards for quantitative mass spectroscopy
(MS) analysis.
Sulfur-containing cymantrene derivatives having one or two organometallic moieties were studied by NMR, IR, UV/Vis spectroscopic methods and CVA under irradiation conditions. Photolysis of compounds 1-3 leads to the formation of rare 4membered chelates 4, 5 and 8. In the presence of external ligand (L), dissociation of the MnÀ S bond occurred to form new dicarbonyl complexes with the MnÀ L bond, which demonstrates the hemilabile character of the chelates obtained. The results were confirmed by DFT calculations. CVA method showed manganese oxidation potential value increased in the case of dicarbonyls (1313 mV for 4) as compared to that of tricarbonyls (1067 mV for 1).
The synthesis of four new 1,2,3‐triazole derivatives and seven 1,2,3‐triazolium salts that contain an organometallic group (i.e., cymantrenyl and ferrocenyl) at either the N‐1, N‐2, or N‐3 position was realized. The alkylation of organometallic and organic triazole derivatives was investigated, and as a result of these studies, it was found that the presence of a good leaving group at the heterocyclic nitrogen atom led to transalkylation and subsequent migration of the N‐1 substituent to the N‐2 position of the triazole moiety. The nucleophilicity of the counterion of the triazolium salt influenced the transalkylation and isomerization processes, which suggests that the elimination of the N‐substituent most likely occurs though a concerted mechanism with nucleophilic assistance from the counterion. Thus, a new approach to the synthesis of 2,4‐disubstituted 1,2,3‐triazoles has been developed.
Enantiomeric-enriched ferrocene-modified pyrazoles were synthesized via the reaction of the ferrocene alcohol, (S)-FcCH(OH)CH3 (Fc = ferrocenyl), with various pyrazoles in acidic conditions at room temperature within several minutes. X-ray structural data for racemic (R,S)-1N-(3,5-dimethyl pyrazolyl)ethyl ferrocene (1) and its (S)-enantiomer (S)-1 were determined. A series of racemic pyrazolylalkyl ferrocenes was separated into enantiomers by analytical HPLC on β- and γ-cyclodextrins (CD) chiral stationary phases. The quantum chemical calculations of interaction energies of β-CD were carried out for both (R)- and (S)-enantiomers. A high correlation between experimental HPLC data and calculated interaction energies values was obtained.
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