The use of geminal di(guanidinium) and acridin-9(10H)-one-derived di(carboxylate) derivatives (1a− c and 2a−e, respectively) allows stabilization of heterodimers characterized by high binding affinities in water (maximum ΔG < −7 kcal mol −1 , K a > 10 5 M −1 ) as inferred from UV−vis spectroscopic titrations and ITC measurements, therefore rivaling or surpassing the interaction energy between the strongest DNA or RNA triplet pairs. These duplexes are readily accessible and are structurally modifiable, rendering them attractive as building blocks for creating heteroduplex constructs. Incorporating poly(ethylene glycol)-decorated benzyl groups into the dicarboxylate, allows formation of hydrogels in the case of 1b−2c.
A supramolecular polymer that allows for intrapolymer proton-coupled photoinduced electron transfer was constructed by means of amidinium-carboxylate salt bridges.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.