Drug-drug, drug-formulation and drug-meal interactions are of clinical concern for orally administered drugs that possess a narrow therapeutic index. This review presents the current status of information regarding interactions which may influence the gastrointestinal (GI) absorption of orally administered drugs. Absorption interactions have been classified on the basis of rate-limiting processes. These processes are put in the context of drug and formulation physicochemical properties and oral input influences on variable GI physiology. Interaction categorisation makes use of a biopharmaceutical classification system based on drug aqueous solubility and membrane permeability and their contributions towards absorption variability. Overlaying this classification it is important to be aware of the effect that the magnitudes of drug dosage and volume of fluid administration can have on interactions involving a solubility rate limits. GI regional differences in membrane permeability are fundamental to the rational development of extended release dosage forms as well as to predicting interaction effects on absorption from immediate release dosage forms. The effect of meals on the regional-dependent intestinal elimination of drugs and their involvement in drug absorption interactions is also discussed. Although the clinical significance of such interactions is certainly dependent on the narrowness of the drug therapeutic index, clinical aspects of absorption delays and therapeutic failures resulting from various interactions are also important.
It has a strict demand for the transverse thickness difference of silicon steel. To reduce the transverse thickness difference of the cold rolled strip, it must reduce the crown and the wedge of the hot rolled strip. 7-Stands continuously variable crown (CVC) hot rolling mills are conventionally applied to roll silicon steel. However, the CVC rolling mills have many defects to roll silicon steel as a result of the strict demands for the crown and the wedge and the characteristics of the CVC rolling mill. The large concave roll (LCR) technology was puts forward to solve that problem. The LCR technology includes the design of the roll contour and the roll free shifting strategies. The results of simulations and experiments show that the LCR technology can not only ensure the crown target of silicon steel, but also enlarge the coil quantity in a rolling schedule and improve the hot rolled strip edge-drop in the late of rolling schedule. This technology provides guidance for the crown control of the hot rolled silicon steel.
In order to enhance the cooling efficiency of plate-fin motor cooler, two kinds of plate-fin-tubes were proposed, which named triangle-wing and convex fin-tube. The heat transfer characteristics of fin-tubes are investigated via numerical simulation and experiment. The result showed that the k-ε turbulence model is highly accurate in simulation of cooler, and the deviation of average heat transfer coefficient and frictional pressure drop between experiment and simulation is within 10% and 8%, respectively. Both of the triangle-wing and convex fin-tube can increase the heat transfer efficiency of plate-fin cooler. The frictional pressure drop also has an approximate variation trend. In addition, the pressure drop of convex-fin-tube is smaller than triangle-wing-fin-tube on the premise of the same heat transfer coefficient, so the heat transfer performance of convex-fin-tube is the best.
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