Increased antibiotic resistance poses a major limitation in tackling inflammatory bowel disease and presents a large challenge for global health care. Antimicrobial peptides (AMPs) are a potential class of antimicrobial agents. Here, we have designed the potential oral route for antimicrobial peptide R7I with anti-proteolytic properties to deal with bacterial enteritis in mice. The results revealed that R7I protected the liver and gut from damage caused by inflammation. RNA-Seq analysis indicated that R7I promoted digestion and absorption in the small intestine by upregulating transmembrane transporter activity, lipid and small molecule metabolic processes and other pathways, in addition to upregulating hepatic steroid biosynthesis and fatty acid degradation. For the gut microbiota, Clostridia were significantly reduced in the R7I-treated group, and Odoribacteraceae, an efficient isoalloLCA-synthesizing strain, was the main dominant strain, protecting the gut from potential pathogens. In addition, we further discovered that R7I reduced the accumulation of negative organic acid metabolites. Overall, R7I exerted better therapeutic and immunomodulatory potential in the bacterial enteritis model, greatly reduced the risk of disease onset, and provided a reference for the in vivo application of antimicrobial peptides.
This article addresses the adaptive attitude tracking control based on similar skew-symmetric structure. Based on the structure, a novel adaptive backstepping scheme is proposed to design the attitude controller. To avoid unwinding, a rotation matrix rather than a quaternion is used to describe the attitude. Correspondingly, the application of similar skew-symmetric structure is extended from euclidean space to noneuclidean space, for which the stability is proved by combining the Lyapunov function and the Morse-Lyapunov function. In addition, the smooth projection function is adopted to design the adaptive law for the unknown parameters. And the input-to-state stable property of the closed-loop system is proved when considering the unmodeled disturbance. Finally, numerical simulations are carried out to illustrate the effectiveness of the proposed controllers.
This paper addresses the attitude tracking problem of observation spacecraft, which is traveling around the target spacecraft. To observe the target spacecraft completely, view planning technology is used to select the optimal viewpoints where the observation spacecraft need to achieve and scans the target spacecraft. The desired attitude and desired angular velocity are determined by the relative location and relative velocity of the observation spacecraft with respect to the target spacecraft. The attitude tracking model are globally and uniquely described in the space of SO(3) × R 3 . Based on the sliding mode method, a nonlinear feedback controller is designed to track the desired attitude and desired angular velocity. The convergence and stability of the closed-loop system are assured by Morse-Lyapunov theorem and LaSalle's theorem. Moreover, it is proved that the attitude error and angular velocity error converge to a tolerable error interval regardless of actuator misalignment, uncertainties of the inertia matrix and external disturbed torque. In addition, the convergence interval is determined by the parameter setting in the controller. Finally, numerical simulations are presented to illustrate the effectiveness of the proposed controller.
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