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Abstract. Given a positive function F on S n which satisfies a convexity condition, for 1 ≤ r ≤ n, we define the r-th anisotropic mean curvature function H F r for hypersurfaces in R n+1 which is a generalization of the usual r-th mean curvature function. We prove that a compact embedded hypersurface without boundary in R n+1 with H F r = constant is the Wulff shape, up to translations and homotheties. In case r = 1, our result is the anisotropic version of Alexandrov Theorem, which gives an affirmative answer to an open problem of F. Morgan.