Cationic cyclopentadienyliron complexes of chloro-substituted arenes were found to perform efficient Pd-catalyzed cross-coupling reactions with arylboronic acids under mild conditions. Using this method, some new cationic cyclopentadienyliron complexes of biaryl derivatives (Fc−Bi) were obtained with good yields. After a photolysis reaction of the obtained Fc−Bi, some biaryl derivatives were easily obtained. Results in the present study provided a practical route to the preparation of Fc−Bi and biaryl derivatives.
Highlights
BEBT-109 is a potent pan-mutant-selective EGFR inhibitor.
Pharmacokinetic profiles of BEBT-109 minimize the off-target toxicity.
Two major metabolites of BEBT-109 show no wild-type EGFR inhibition.
BEBT-109 demonstrates potent antitumor activity in the clinical trial.
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