Internet of Things (IoT) and cloud computing are increasingly integrated, in the sense that data collected from IoT devices (generally with limited computational and storage resources) are being sent to the cloud for processing, etc., in order to inform decision making and facilitate other operational and business activities. However, the cloud may not be a fully trusted entity, like leaking user data or compromising user privacy. Thus, we propose a privacy-preserving and user-controlled data sharing architecture with fine-grained access control, based on the blockchain model and attribute-based cryptosystem. Also, the consensus algorithm in our system is the Byzantine fault tolerance mechanism, rather than Proof of Work.
The outbreak of avian influenza virus H5N1 has raised a global concern because of its high virulence and mutation rate. Although two classes of antiviral drugs, M2 ion channel protein inhibitors and neuraminidase inhibitors, are expected to be important in controlling the early stages of a potential pandemic. Different strains of influenza viruses have differing degrees of resistance against the antivirals. In order to analyze the detailed information on the viral resistance, molecular dynamics simulations were carried out for the neuraminidase (NA) complex with oseltamivir. The carboxylate of Glu276 of H252Y NA faces toward the O-ethyl-propyl group of oseltamivir, Glu276 of wild-type NA adopts a conformation pointing away from the oseltamivir. τ2 and τ3 torsional angles fluctuation of the oseltamivir are relatively high for the H252Y mutant NA complex. In addition, there are fewer hydrogen bonds between the oseltamivir and H252Y mutation NA. The results show that H252Y mutation NA has high resistance against the drug.
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