A sequential and efficient protocol for the synthesis of α-thiolated enaminones has been developed under copper-TEMPO systems. This reaction features a broad substrate scope to obtain the desired product in...
A general
and efficient method for the synthesis of 4-sulfenylated
oxazoles is described. Trisubstituted oxazoles are obtained in good
to excellent yields from β-keto sulfoxides and nitriles. The
mechanistic study suggests that the reaction proceeds via the nucleophilic
addition of nitriles to the in situ formed α-carbonyl cation
followed by intramolecular cyclization.
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