Stimuli-sensitive hydrogels are ideal candidates for biomedical and bioengineering purposes, although applications of hydrogels may be limited, due in part to the limited choice of suitable materials for constructing hydrogels, the complexity in the synthesis of the source materials, and the undesired fast-then-slow drug-release behaviors of usual hydrogels. Herein, we describe the fabrication of a new supramolecular guanosine (G)-quadruplex hydrogel by multicomponent self-assembly of endogenous guanosine (G), 2-formylboronic acid (2-FPBA), and tris(2-aminoethyl)amine (TAEA) in the presence of KCl in an easy and convenient way. The features of the G-quadruplex hydrogel include (1) versatility and commercial availability of building blocks with different functions, (2) dynamic iminoboronate bonds with pH and glucose responsiveness, and (3) zero-order drug-release behavior because of the superficial peel-off of the hydrogel in response to stimuli. The structure, morphology, and properties of the G-quadruplex hydrogel were well-characterized, and satisfactory zero-order drug release was successfully achieved. This kind of supramolecular G-quadruplex hydrogels may find applications in biological fields.

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These findings suggest that H19 mediated the antiapoptotic effect of H/Post against H/R-induced injury to aged cardiomyocytes by inhibiting miR-29b-3p expression.

In order to study the mechanism of biomass tar formation and elimination in a two-stage downdraft gasifier, the nascent rice straw pyrolysis tar evolution properties under homogeneous/heterogeneous decomposition conditions have been investigated in a constructed lab-scale two-stage reactor by varying factors as temperature, concentration and reforming agents of CO 2 /H 2 O/O 2 , and char bed heights. The nascent tar was produced in the first stage reactor and then decomposed in the second stage with different reforming agents or char beds. In the first stage, the results showed that nascent pyrolysis tar yields increased with increasing pyrolysis temperature, tar was mainly produced during 200À400°C, and 400À500°C would be a proper pyrolysis temperature range in commercial operation due to little effect on tar yields in higher temperature. In the second stage, it can be observed that nascent biomass tar was converted into polycyclic aromatic hydrocarbons (PAHs) (even soot), thermally stable one ring aromatics, and noncondensable gases in homogeneous conditions with increasing temperature. Different effects were obtained in varying tar species under different homogeneous reforming agents. However, benzene, toluene, styrene, phenol, and naphthalene are the most typical compounds, accounting for 50À75% in total tar concentration at 900°C in all decomposition conditions. Char bed can selectively reduce PAH species remarkably and increase the toluene yields. As for the three reforming agents, steam showed the highest efficiency in tar elimination, while CO 2 and O 2 present will induce OH, H, and O radicals formation, which increases hydrocarbon conversion. The mechanism of tar destruction in a two-stage downdraft gasifier can be concluded as follows: nascent tar yields from the pyrolysis stage will be first reformed into PAHs, thermally stable one ring aromatics and noncondensable gases in the throat region, and then PAHs species are almost completely decomposed by the char bed, which are the main troublesome tar components in syngas, and finally the syngas with low tar was obtained.