The objective of this study is to identify the relationships in which social support influences flow and game loyalty through character control, character identity, guild identity and self-esteem. For the study, focus group interviews were carried out with MMORPG gamers and, as a result, important factors such as social support and self-esteem were found. Based on prior research and the focus group interviews with MMORPG gamers, the independent variables of social support and character control were identified. Character identity, guild identity and self-esteem are proposed as mediating variables with flow and loyalty as the dependent variables. The research model and hypotheses were developed and then verified empirically. The data was collected from 244 WOW gamers to verify the research model and SEM analysis was then used to test goodness-of-fit of the model. The results were as follows: First, social support had a statistically significant impact on character control, character identity, guild identity and self-esteem. Second, character control had significant effects on character identity, guild identity and self-esteem. Third, character identity had a clear effect on self-esteem. Fourth, guild identity affected self-esteem, flow and loyalty. Fifth, self-esteem had a positive influence on flow.

No abstract

e14552 Background: YBL-006 is an anti-programmed death-1 (PD-1) antibody with a higher affinity compared to that of other PD-1 antibodies, which showed a favorable safety profile in animal models. We designed the first-in-human phase I trial of YBL-006 to assess its safety and efficacy with exploratory biomarker analysis in patients with advanced solid tumors refractory to standard of treatment. Methods: A modified “3+3” design, with the first patient dosed at 0.5 mpk, was followed by conventional dose escalation of 2, 5, and 10 mpk IV. Pharmacokinetics (PK) and pharmacodynamics, including PD-1 receptor occupancy (RO) and serum levels of interferon-gamma (IFN-γ), were assessed. Adverse events (AEs) were graded using the CTCAE v4.03. Tumor response was assessed using the RECIST v1.1 every 8 weeks. For exploratory analysis, tumor mutational burden (TMB) and AI-powered spatial analysis of tumor-infiltrating lymphocyte (TIL) of tumor tissues collected before YBL-006 treatment were performed. The cut-off date for analysis was February 12, 2021. Results: A total of 8 patients enrolled in the 0.5, 2, and 5 mpk cohorts received at least one dose of YBL-006 and median exposure was 15 weeks (ranged 4-26). No dose limiting toxicity occurred and the maximum tolerated dose was not reached until progressing to the 5 mpk. The common treatment-related AEs were G1 fatigue (25%), and G1 hypothyroidism (12.5%). We also observed 1 case of G2 cytokine release syndrome during cycle 1 in 2 mpk which was managed with supportive care alone. No treatment-related deaths have occurred to date. YBL-006 showed a linear PK prolife and both PD-1 RO and serum IFN-γ increased by > 2 times 8 h after the first dose. Tumor evaluation data were available for 7 patients, which showed 1 confirmed complete response (CR, penile squamous cell carcinoma, 2 mpk) and 1 confirmed partial response (PR, anal squamous cell carcinoma, 2 mpk) with durable responses lasting more than 19+ and 10+ weeks respectively, 2 stable disease (SD) and 3 progressive disease (PD). Four tumor samples were available for biomarker analysis. TMBs of patients with CR (8.3/Mb) or PR (9.3/Mb) were higher than those in 2 patients with PD (5.5 and 1.7/Mb). AI-powered spatial analysis of TIL showed that intratumoral TIL density was increased in patients who achieved CR and PR (66.1% and 95.8%, respectively) compared to those in patients who exhibited PD (25.1% and 16.5%, respectively). Conclusions: Interim analysis of phase I study showed that YBL-006 is well tolerated and preliminary biomarker analysis showed that the TMB, and intratumoral TIL infiltration are potentially related to the response to YBL-006. Clinical trial information: NCT04450901.