Prevention of the occurrence and development of inflammation is a vital therapeutic strategy for treating acute lung injury (ALI). Increasing evidence has shown that a wealth of ingredients from natural foods and plants have potential anti-inflammatory activity. In the present study, mangiferin, a natural C-glucosyl xanthone that is primarily obtained from the peels and kernels of mango fruits and the bark of the Mangifera indica L. tree, alleviated the inflammatory responses in lipopolysaccharide (LPS)-induced ALI mice. Mangiferin-modified magnetic microspheres (MMs) were developed on the basis of click chemistry to capture the target proteins of mangiferin. Mass spectrometry and molecular docking identified 70 kDa heat-shock protein 5 (Hspa5) and tyrosine 3-monooxygenase (Ywhae) as mangiferin-binding proteins. Furthermore, an enzyme-linked immunosorbent assay (ELISA) indicated that mangiferin exerted its anti-inflammatory effect by binding Hspa5 and Ywhae to suppress downstream mitogen-activated protein kinase (MAPK) signaling pathways. Thoroughly revealing the mechanism and function of mangiferin will contribute to the development and utilization of agricultural resources from M. indica L.

The previous literature on the resource curse has not taken resource price fluctuations into account. Using panel data covering the period from 1993 to 2017 from 28 provinces in China and dynamic generalized method of moments (GMM), this article takes a fresh look at the relationship between resource dependence and sustainable economic growth and the potential transmission mechanisms taking resource price fluctuations into consideration. We find that resource price fluctuations represent an important factor when researching the resource curse, and there is a U-shaped relationship between resource dependence and sustainable economic growth. However, over the past 20 years, provinces in China remained on the left of the U-shaped curve, and there is a single negative correlation between resource dependence and sustainable economic growth. This means that resource curse occurs in nearly all provinces in China. The analysis of transmission mechanisms of indirect effects taking resource price fluctuations into consideration shows that human capital investment and physical capital investment are more important than other mechanisms, and there are considerably more indirect effects than direct effects when taking into account the total effects of the resource curse.

The genesis of the overpressure carbonate reservoir is not controlled only by lithofacies, karstification and tectonic movement, but also by overpressure. The hydraulic fractures formed under overpressure and its connection and expansion to early solution vugs and structural fractures are the key factors to the high productive zones. Kenkiyak Pre-salt Oilfield is the carbonate reservoir with a burial depth of more than 4300 meters. The matrix permeability is only 0.98md. It was considered as a very low permeability porous-type reservoir and was defined as the oilfield without economic benefit. According to this study, under the overpressure condition, that the pressure of the porous liquid is up to 80Mpa, the carbonate reservoir cracks to form natural hydraulic fractures. Reticulate hydraulic fractures combined with structural fractures and solution vugs make very good spatial configuration, and then form the pore-fractural dual- media reservoir. The high productive reservoirs form under the condition of the favorable sedimentary facies, karstification cells and structural locations. Because of the overlying salt-dome with 120–3800 meters in thickness, the imaging of the seismic data is very poor and it is very difficult to predict reservoirs. The seismic processing techniques such as kirehhoff prestack time migration, diving wave tomo and CIP grid tomography are applied to improve the migration image and signal-noise ratio. Based on analysis of the control factors to the carbonate reservoir, using the data of the drilling, logging and dynamic test data, the lithofacies, palaeokarst and the fracture system are predicted and the distribution of the high productive zone is successfully predicted by applying the techniques of the seismic muti-attribute clustering analysis and seismic inversion. The average productivity of the new drilling wells in the predicted high productive zones is up to 300t/d, and the oil rate per day of the 2 wells is over 1000t.

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