In this Letter, triazoles as carbene reagents were used
for sulfonamide-directed
C–H insertion carbenoid functionalization to construct benzylpyridine
sulfonamide dual-pharmacophore compounds. This method is simple and
efficient and can be used for the late-stage modification of sulfonamide
drugs.
A novel CuII-mediated synthesis of aryl α-keto amides from epoxide derivatives is reported. This transformation was conducted by using O2 as a green oxidant that meets the requirements of sustainable chemistry.
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