Determining the effect of Bryophyllum pinnatum treatment in modulating immune response and the pregnancy outcomes of pregnant pristane-induced lupus mice model. Sixteen Balb/c mice were intraperitoneally injected with single 0.5 cc pristane to induce lupus manifestations. After 12 weeks of injection, mice were mated and considered as gestational day 0 (GD0). Mice were divided into 4 groups based on the dosages of Bryophyllum pinnatum: control (no treatment), B1 (10.5 mg/kg), B2 (21 mg/kg), and B3 (42 mg/kg). The treatment was given orally every day started from GD9 until 9 days. At the end of the study, blood pressure and fetal size were measured. Serum anti-dsDNA and urine albumin levels were measured by ELISA. Spleen T helper (Th) and mature B cells percentages were measured by flow cytometry. Administration of Bryophyllum pinnatum reduced the percentages of Th1 (p=0.006), Th2 (p=0.005), Th17 (p=0.000), and mature B cells (p=0.007) in dosedependent manner. B1 and B2 had significantly lower of systolic blood pressure compared to control (p=0.026 and p=0.022 respectively). Significantly lower of anti-dsDNA levels were found in B1 group compared to control (p=0.014). However, no significantly different of urine albumin levels were found between groups. Bryophyllum pinnatum also significantly increased the fetus body weight in dosedependent manner (p=0.000). Treatment of Bryophyllum pinnatum could improve the pregnancy outcome and modulate the immune response in pregnant pristaneinduced lupus mice. Therefore, Bryophyllum pinnatum is a potential herb, which can be developed as an immunosuppressive agent in the future.
Background: The goal of this study is to see how elderly gymnastics affect blood pressure, plasma glucose levels, and total cholesterol levels in women over the age of 65. Objective: The purpose of this study is to look into the effects of gymnastics on changes in blood pressure, blood sugar levels, and total cholesterol levels in the elderly.. Methods: Thirty-four female elderly women were divided into two groups: those who received gymnastics and those who did not. For three weeks, regular gymnastics exercises were performed on a weekly basis. Blood pressure, plasma glucose levels, and total cholesterol levels were measured using standard techniques and methods. Results: When compared to controls, regular gymnastics exercise can significantly lower blood pressure ( p < 0.05). This decrease is also observed in total cholesterol levels ( p < 0.05). Conclusions: Elderly gymnastics was found to lower blood pressure and total cholesterol levels in the elderly. As a result, elderly gymnastics could be a viable option for preventing cardiovascular disease and metabolic syndrome.
The leaves of Bandotan (Ageratum conyzoides) are a plant thought to have antibacterial properties. This study aims to determine the sensitivity of Bandotan leaf extract in inhibiting the growth of the bacteria Pseudomonas aeruginosa. This study used a stock extract of Bandotan leaves from the Pharmacology Laboratory and a bacterial isolate of P. aeruginosa in the Microbiology Laboratory of the Faculty of Veterinary Medicine, Universitas Syiah Kuala, which was identified by Gram staining, indole test, Methyl Red test, and confectionery test. The research method was carried out by planting the re-identified bacterial isolates on Nutrient Broth (NB) media, incubated at 37ºC for 24 hours. Then the turbidity composition of the isolates was arranged to match the turbidity in 0.5 McFarland solution. Furthermore, the sensitivity test of the extract on Mueller Hinton Agar (MHA) media was carried out by levelling the bacterial isolates on the surface of the media and attaching a disc containing bandotan leaf extract with a concentration of 25%, 50%, 75% and gentamicin disk as a positive control and distilled water as a negative control. All treatments were incubated at 37ºC for 24 hours, and then the inhibition zone was measured using millimeters (mm) callipers. The results showed that concentrations of 25%, 50% and 75%, respectively, had an inhibition zone of 8.16 mm, 9.82 mm, and 16.08 mm, respectively. In contrast, the average inhibition zone for gentamicin was 25, 30 mm and 0 mm distilled water. Therefore, it can be concluded that the Bandotan leaf extract is sensitive to growth inhibition of P. aeruginosa bacteria.
Penelitian pada peserta didik Kelas VII Semester II MTs Ma’arif Nu 8 Siandong-Larangan Kabupaten Brebes bertujuan untuk mendiskripsikan: (1) pembelajaran matematika yang diajar menggunkan model pembelajaran open-ended melampaui target, (2) model pembelajaran open-ended lebih baik dari pada model pembelajaran konvensional terhadap keaktifan belajar matematika, (3) model pembelajaran open-ended lebih baik dari pada model pembelajaran konvensional terhadap kemampuan pemecahan masalah matematika, (4) perbedaan signifikan setelah diajar dengan model pembelajaran open-ended dan model pembelajaran konvensional terhadap keaktifan belajar dan pemecahan masalah matematika, (5) model pembelajaran open-ended lebih baik daripada model pembelajaran konvensional terhadap keaktifan belajar dan pemecahan masalah matematika.Populasi dalam penelitian ini adalah peserta didik kelas VII MTs Ma’arif Nu 8 Siandong-Larangan Kabupaten Brebes yang terdiri dari 7 kelas sebanyak 184 peserta didik. Teknik pengambilan sampel menggunakan cluster random sampling. Metode pengumpulan data menggunakan dokumentasi, observasi dan tes. Instrumen penelitian berupa tes dalam bentuk essay yang telah diuji validitas, reliabilitas, tingkat kesukaran soal dan daya beda. Teknik Analisis data menggunakan uji proporsi satu pihak kanan, uji t satu pihak kanan, uji analisis varians multivariat satu arah dan uji- Hotelling. Hasil penelitian menyatakan bahwa: (1) pembelajaran matematika yang diajar menggunakan model pembelajaran open-ended telah melampaui target, (2) pembelajaran open-ended lebih baik dari pada model pembelajaran secara konvensional terhadap keaktifan belajar (3) pembelajaran open-ended lebih baik dari pada model pembelajaran secara konvensional terhadap pemecahan masalah matematika, (4) ada perbedaan signifikan setelah diajar dengan model pembelajaran open-ended dan model pembelajaran konvensional terhadap keaktifan belajar dan pemecahan masalah matematika, (5) pembelajaran menggunakan model pembelajaran open-ended lebih baik daripada model pembelajaran konvensional terhadap keaktifan dan pemecahan masalah.
This article explains about the administration of a school. administration is a part of the school that functions as a support for teaching and learning activities so that it runs smoothly according to what has been planned and can be achieved as desired. This article also explains how the teacher's role as an educator in the administration of administration and how to lay out an office or school in a blind. The purpose of this article is to explain how the administration of administration in schools or offices so that educational goals can be achieved effectively.
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