Introduction Data concerning the impact of amphetamine on male sexual functions are limited, although amphetamine has been used as an aphrodisiac. Aims This cross-sectional study was to assess the impact of illicit use of amphetamine on male sexual functions. Methods Male illicit drug users in a Drug Abstention and Treatment Center were recruited to complete a self-administered questionnaire, and data were compared with age-matched controls. Main Outcome Measures The International Index of Erectile Function (IIEF) and global assessment questions were used to assess sexual functions. Results Of 1,159 amphetamine mono-illicit drug users, the mean age was 31.9 ± 7.5 (18–57) years, and mean duration of drug use was 30.7 ± 52.2 (median 9, range 0.1–252) months. Half of them reported that drug use had no impact on their sexual functions. The other half reported drug impacts as reduced erectile rigidity and sexual life satisfaction, enhanced orgasmic intensity, and prolonged ejaculation latency time more often than the opposite effects, while they reported enhanced or reduced effect equally on sexual desire. Dosing frequency of amphetamine was associated with its impact on sexual functions, but duration of its use had little association with that. Compared with 211 age-matched controls, the amphetamine mono-illicit drug users had lower IIEF scores in the domains of erectile function, orgasmic function, and overall satisfaction, but there are no significant differences in intercourse satisfaction and sexual desire scores. The prevalence of erectile dysfunction (ED) was significantly higher in the drug users than in the controls (29.3% vs. 11.9%). The odds ratio of ED for amphetamine use was 2.1 (95% confidence interval 1.2–3.6) after adjustment for other risk factors. Conclusions The impact of illicit use of amphetamine on male sexual functions varied among users, and their ED prevalence was higher than the controls.
IntroductionAreca nut chewing has been shown to increase the risk of cardiovascular disease, but its association with erectile dysfunction (ED) has not been investigated.AimTo investigate the association between areca nut chewing and risk of ED.MethodsConsecutive men at public health centers for oral malignancy screening or health checkup were invited to complete a questionnaire.Main Outcome MeasureThe Sexual Health Inventory for Men (SHIM).ResultsOf the 2,652 respondents, 1,038 (mean age = 43.8 ± 11.1 years) were eligible for the areca nut chewing group and 1,090 non-areca nut chewers were selected as the age-matched control group. In the areca nut group, the mean duration of chewing was 13.2 ± 9.6 years, 61.7% consumed more than 10 portions per day, and 76.2% used it with betel leaf, 16.7% used it with betel inflorescence, and 7.1% used it with betel leaf and inflorescence. Smoking, alcohol drinking, obesity, hypertension, and diabetes were more predominant in areca nut chewers compared with controls. ED defined by self-report and by SHIM score was more prevalent in areca nut chewers than in controls (13.7% vs 9.8% and 48.7% vs 43.3%, respectively; P < .05 for the two comparisons). Areca nut use with betel inflorescence was associated with a higher risk of ED (odds ratio = 2.25, 95% confidence interval = 1.55–3.28) with a dose-dependent effect, whereas using it with betel leaf was not (odds ratio = 1.00, 95% confidence interval = 0.79–1.26) after adjustment of possible confounders.ConclusionAreca nut chewing with betel inflorescence was associated with an increased risk of ED. These findings warrant further studies.Huang Y-J, Jiann B-P. Association of Areca Nut Chewing With Risk of Erectile Dysfunction. Sex Med 2017;5:e163–e168.
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