Ikoamide (1) is a highly N-methylated antimalarial
lipopeptide that was isolated from a marine cyanobacterium, an Okeania sp. in 2018, which shows strong antimalarial activity
without cytotoxicity against human cancer cell lines. To establish
a synthetic method for obtaining enough ikoamide for its biological
evaluations, we have established a total synthesis of ikoamide. The
synthetic method presented here lays the foundation for the development
of novel ikoamide analogues, which may lead to a discovery of pharmaceutically
unique antimalarial drug leads.
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