Oxy-/amino-difluoromethylthiolation of β,γ-unsaturated oximes/hydrazones have been developed for construction of HCF 2 S-containing isoxazolines and pyrazolines by employing PhSO 2 SCF 2 H as difluoromethylthiolation reagent under mild conditions. Such transformations exhibit good functional group tolerance and scalability. Possible mechanisms are proposed.
An oxidative azido-difluoromethylthiolation of alkenes
by employing
TMSN3 as the azide source and PhSO2SCF2H as the difluoromethylthiolation reagent is reported. The present
method is characterized by good functional group tolerance, broad
substrate scope, and short reaction time, thereby providing an efficient
access to synthetically useful β-difluoromethylthiolated azides.
Mechanistic studies indicate a radical pathway involved in the reaction.
A copper-catalyzed cascade multicomponent reaction for synthesizing ditriazolyl diselenides from azides, terminal alkynes, and elemental selenium has been developed. The present reaction features utilizing readily available and stable reagents, high atom-economy, and mild reaction conditions. A possible mechanism is proposed.
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