1. Heart rate (HR) turbulence describes short-term sinus rhythmic fluctuation after a single premature ventricular beat. Turbulence onset (TO) and turbulence slope (TS) are two essential parameters in HR turbulence. Turbulence onset and TS have been used to evaluate cardiac autonomic nerve function. 2. In the present study, we measured the HR turbulence in dilated cardiomyopathy (DCM) and determined the possible role of benazepril, an angiotensin-converting enzyme inhibitor (ACEI), on these parameters. There were three groups: control, DCM and DCM treated with benazepril. The control group consisted of normal subjects with PVB, but no structural heart disease. Ambulatory electrocardiogram, blood pressure and echocardiography were analysed. 3. There was an increase in TO and a decrease in TS in DCM patients. Benazepril treatment (10 mg/day, p.o.) reduced those changes. There were no significant differences in blood pressure and left ventricular ejection fraction (LVEF) between DCM patients and DCM patients treated with benazepril. 4. Linear regression analysis showed that TO was negatively correlated with LVEF, whereas TS was positively correlated with LVEF, in the DCM group. After benazepril treatment, the correlations between TO and TS and LVEF disappeared. 5. It is concluded that the TO and TS of HR turbulence are altered in patients with DCM. These alterations indicate a dysfunction of the autonomic control of cardiac electrophysiology in DCM patients. Although TO and TS are correlated with LVEF in DCM patients, the effect of benazepril in improving HR turbulence parameters is not a result of its action on heart function, which suggests a new beneficial effect of ACEI in the treatment of DCM patients.
Objective To probe into the relation of the angiotensin converting enzyme (ACE) gene polymorphisms and the risk factor with coronary heart disease (CHD) in the Hainan Li and Han nationality. Methods Used the polymerase chain reaction (PCR) to detect the polymorphisms of ACE gene insertion/deletion (I/D) in 150 patients with CHD and 150 healthy people from Hainan Li and Han nationality. The genotype frequencies and allele frequencies of DD, DI and II were observed. Specifi c PCR detection was performed for patients who have been determined as DD by normal PCR to reduce misclassifi cation rate. Results In the CHD group of Hainan Li nationality, the genotype frequencies of DD, DI and II were 24.7%, 32.7%, 42.6% respectively, and the allele frequencies of D and I were 41.0% and 59.0%. In the healthy control of Hainan Li nationality, the genotype frequencies of DD, DI and II were 14.0%, 44.0%, 42.0% respectively, and the allele frequencies of D and I were 36.0% and 64.0%. There were signifi cant differences both in the genotype frequencies of DD, DI and II, and in allele frequencies D and I between these two groups (p<0.05). In the CHD group of Hainan Han nationality, the genotype frequencies of DD, DI and II were 23.3%, 45.4%, 31.3% respectively, and the allele frequencies of D and I were 46.0%, 54.0%. In the healthy control of Hainan Han nationality, the genotype frequencies of DD, DI and II were 13.3%, 42.0%, 44.7% respectively, and the allele frequencies of D and I were 34.3%, 65.7%. There were signifi cant differences both in the genotype frequencies of DD, DI and II, and in allele frequencies D and I between these two groups (p<0.05). The multiple logistic regression analysis showed that the triglyceride (TG) level in the CHD group was signifi cantly higher than in the control (p<0.05) and the high density lipoprotein cholesterol (HDL-C) level in the CHD group was signifi cantly lower than the control in both nationality (p<0.05). Conclusions There were notable correlation between the ACE gene I/D polymorphisms and the CHD in Hainan Li and Han nationality. The ACE gene polymorphisms are the major gene changes that may cause CHD in Hainan Li and Han nationality. The higher TG level and the lower HDL-C level may be risk factors in Hainan Li and Han nationality.
coronary arteries were assessed by Gensini scoring system. The fasting serum concentrations of CatS and CysC were measured before angiography respectively. The SPSS11.0 system was applied to analyse the data. Compared with controls, serum levels of cathepsin S in CAD groups increased significantly and demonstrated positive correlation (r¼0.69, p¼0.0001)with Gensini score. After being corrected for other common factors (age, sex, blood pressure and blood lipid, etc) by multivariate stepwise regression analysis, this relationship also existed. Conclusions Serum levels of cathepsin S are associated with severity of athero sclerostic lesions of coronary arteries. The higher serum levels of cathepsin S are, the severer atherosclerostic lesions of coronary arteries are. Objective The aim of the prospective study was to investigate the clinical and laboratory features of individuals with micro creatine kinase type 1 (MCK-1), and to evaluate the clinical significance of these cases who expressed serum MCK-1. Methods To screen MCK-1individuals from serum samples in our biochemistry laboratory from April 2002 to April 2010 according to both increasing CK-MB activity and CK-MB/CKratio over 25%, and finally confirmed by agarose gel electrophoresis of CK isoenzyme analysis. To analyse the clinical and laboratory data of individuals who expressed serum MCK-1 isoenzyme. Results MCK-1 was detected in the samples from 30 subjects. Their mean age at the initial presentation was 58.6 years (range 26 to 81), 63.3% were female (n¼19), and 39.3% (n¼11) had hypertension.of the 30 subjects, 10 (33.3%) had increased total CK activity, and 7 (23.3%) showed the abnormal phenomenon that CK-MB:CK ratio was >1. Our study indicated that the misdiagnostic rate was 40.0 % (n¼12), and the rate of missed diagnosis was 46.7% (n¼14). There were 3 deaths during the follow-up period. Conclusion MCK-1 was not rare in clinical practice. Among the conditions in which CK-MB activity is elevated in the absence of myocardial injury or infarction using immunoinhibition methods, MCK-1 merits special attention from clinicians. CK-MB index is a simple and rapid screening test for MCK-I. Objective To study the correlation of the ACE gene polymorphisms with coronary heart disease (CHD) in the Hainan Li nationality. Methods Used the PCR to detect the polymorphisms of ACE gene insertion/deletion (I/D) in 150 patients with CHD and 150 healthy people from Hainan Li nationality. The genotype frequencies and allele frequencies of DD, DI and II were observed. Specific PCR detection was performed for patients who have been determined as DD by normal PCR to reduce misclassification rate. Results In the CHD group of Hainan Li nationality, the genotype frequencies of DD, DI and II were 24.7%, 32.7%, 42.6% respectively, and the allele frequencies of D and I were 41.0% and 59.0%. In the healthy control of Hainan Li nationality, the genotype frequencies of DD, DI and II were 14.0%, 44.0%, 42.0% respectively, and the allele frequencies of D and I were 36.0% and 64.0%. There we...
Objectives To study the correlation between angiotensin converting enzyme (ACE)gene polymorphisms with heart failure in Hainan Han Nationality. Methods ACE I/D gene polymorphisms were detected by polymerase chain reaction (PCR) in 150 cases of heart failure patients and 150 cases of healthy person from Hainan Han nationality, and the genotype frequencies and allele frequencies of DD, DI and II were investigated. Results There were no significant differences in the frequencies of allele and genotypes between the healthy subjects and patients with heart failure of Han nationality. There were no significant differences between the two groups (P > 0.05). Conclusions I/D polymorphism of the ACE gene was not related to heart failure in Hainan Han nationality patients, and was not associated with lipid levels in Hainan Han nationality patients with hypertension. Key words ACE gene; Polymorphisms; Heart failure.
Objective To explore the significance of the ACE gene insertion/ deletion (I/D) polymorphism in peoples of Hainan Li and Han nationality with coronary heart disease (CHD). Methods Used the PCR to detect the polymorphisms of ACE gene insertion/deletion (I/D) in 150 patients with CHD and 150 healthy people from Hainan Han and Li nationality respectively. Observed the genotype frequencies and allele frequencies of DD, DI and II. Specific PCR detection was performed for patients who have been determined as DD by normal PCR to reduce misclassification rate. Meanwhile detected the blood lipid, the lipoprotein, the blood pressure, the blood sugar in all people. Used the multiple regression analysis to find out the risk factor in CHD patients. Results The genotype frequencies of DD in the CHD group of Han and Li nationality are significantly higher than the control group of Han and Li (p<0.05). There were no significant differences in the genotype frequencies of DD, DI and II between the Han and Li with CHD. By the multiple regression analysis it shows: the genotype frequencies of DD in the CHD group of Han and Li nationality increased, the high density lipoprotein cholesterol (HDL-C) level in the CHD group of Han and Li nationality decreased. The triglyceride (TG) level in the CHD group of Han nationality increased. Conclusions The genotype frequencies of DD are associated with CHD. The susceptibility of CHD in Han and Li nationality is the same. Increasing the HDL-C level can protect the CHD patients. The high level of TG is the independent risk factor in Hainan Han people with CHD. e0400 MOBILISE AUTOLOGOUS BONE MARROW STEM CELLS TO REPAIR INFARCTED MYOCARDIUM
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