Serum periostin appears to be a useful biomarker for the development of airflow limitation in asthmatic patients on ICS.

No abstract

A GLCCI1 variant is a risk factor of pulmonary function decline in Japanese patients with asthma receiving long-term ICS treatment. Thus, GLCCI1 may be associated with response to ICS across ethnicities.

Definition of abbreviations: ACT = asthma control test; ECP = eosinophil cationic protein; F = female; FE NO = exhaled nitric oxide; hsCRP = high-sensitivity C-reactive protein; ICS = inhaled corticosteroids; IgE = immunoglobulin E; M = male. Results are presented as means 6 SD, except for IgE [medians (ranges)]. *Number of patients, n = 57; elevated FE NO is defined as equal to or greater than 25 ppb; serum periostin levels are defined using 95 ng/ml as the cutoff point. † Patients who had smoked more than 10 pack-years were not included in the study. ‡

No abstract