A GLCCI1 variant is a risk factor of pulmonary function decline in Japanese patients with asthma receiving long-term ICS treatment. Thus, GLCCI1 may be associated with response to ICS across ethnicities.
Definition of abbreviations: ACT = asthma control test; ECP = eosinophil cationic protein; F = female; FE NO = exhaled nitric oxide; hsCRP = high-sensitivity C-reactive protein; ICS = inhaled corticosteroids; IgE = immunoglobulin E; M = male. Results are presented as means 6 SD, except for IgE [medians (ranges)]. *Number of patients, n = 57; elevated FE NO is defined as equal to or greater than 25 ppb; serum periostin levels are defined using 95 ng/ml as the cutoff point. † Patients who had smoked more than 10 pack-years were not included in the study. ‡
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.