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Fibroblasts and myofibroblasts are major mesenchymal cells in the lamina propria of colon mucosa and in colon cancer tissues. Detailed insight into the highly specific populations of fibroblasts and myofibroblasts is required to understand the integrity and homeostasis of human colon mucosa and colon cancer. Based on gene expression profiles of single cells, we identified fibroblast populations that produce extracellular matrix components, Wnt ligand- and BMP-secreting fibroblasts, chemokine- and chemokine ligand-generating fibroblasts, highly activated fibroblasts, immune-modulating fibroblasts, epithelial cell-modulating myofibroblasts, stimuli-responsive myofibroblasts, proliferating myofibroblasts, fibroblast-like myofibroblasts, matrix producing myofibroblasts, and contractile myofibroblasts in human colon mucosa. In colon cancer tissue, the compositions of fibroblasts and myofibroblasts were highly altered, as were the expressing patterns of genes including BMPs, Wnt ligands, chemokines, chemokine ligands, growth factors and extracellular matrix components in fibroblasts and myofibroblasts. Our work expands the working atlas of fibroblasts and myofibroblasts and provides a framework for interrogating the complexity of stromal cells in human healthy colon mucosa and colon cancer tissues.

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The sustainability of social media is a common subject of study. With the emergence of cultural and creative industries, many studies have begun to explore the advantages and disadvantages of the integration of social media with cultural and creative industries. However, there remains a lack of research on the sustainability of cultural and creative social media. Therefore, the present study uses the example of a non-profit cultural and creative organization as its case. The use of social media content discovery technology explains the sustainable use of cultural and creative social media and how participation and interaction with cultural and creative brands are promoted from the perspective of artists or ordinary people. In addition, the analysis of concrete and abstract information explores how content orientation and brand perception impact emotions and behavior. We use social media content discovery technology to analyze 9529 image posts. The results show that for abstract themes, for example, art or design, people can be more easily guided by information with the help of images, which stimulate positive emotions, resulting in more actual engagement behavior, including posting and sharing. With respect to emotional responses, images with smiles are found to have a significant effect in guiding positive emotions, which are expressed through actions, such as active participation and feedback. By examining the meaning of the information in the images, we find that images with abstract themes have a good connection with the brand image. Although the information is less easily shown, it can guide significant outcomes that are positively correlated with the information. Therefore, strengthening brand image and content themes can effectively consolidate trust in brand content and the sustainable development of cultural and creative social media.

Bi 4 Ti 3 O 12 high-temperature piezoelectric ceramics composed of 0.03 mol (Nb, Ta) 5+ substituting B site and x mol CeO 2 (x = 0-0.05, abbreviated as BCTNT100x) substituting A site were synthesized by the conventional solid-state reaction method. The effects of Ce additive on the structures and electrical properties of resulting Bi 4 Ti 3 O 12 -based ceramics were systematically investigated. In-situ temperature-dependent X-ray diffraction (XRD) confirmed that the phase structure of BCTNT100x ceramics change from orthorhombic structure to tetragonal structure as temperature increased. The ceramics at Ce content x = 0.03 illustrated optimal performances with superior piezoelectric constant (d 33 = 36.5 pC/N), high Curie temperature (T C = 649 • C), and large remanent polarization (2P r = 21.6 μC/cm 2 ). BCTNT3 ceramics also possessed high d 33 of 32.5 pC/N at an annealing temperature of 600 • C, with electrical resistivity preserved at 10 6 Ω cm at 500 • C. These results demonstrate that BCTNT100x ceramics can be used as high-temperature piezoelectric devices.