The aim is the analysis of hyperuricemia influence on the heart features in patients with arterial hypertension. Materials and methods: We include 75 patients with arterial hypertension which were divided in two groups according to the level of uric acid in the blood, 30 practically healthy people. Patients from the I group (n = 40) had arterial hypertension and coexistent hyperuricemia; ІІ (n = 35) – arterial hypertension. Left ventricular mass index was determined for left ventricular hypertrophy confirmation. We used clinical, anthropometric, biochemical, instrumental, statistical method. Serum uric acid level was observed by the reaction with uricase. Left ventricular mass index was calculated as left ventricular mass to body surface area ratio. The results were analyzed statistically by SPSS 21 and Graphpad. Results: Left ventricular mass index was significantly higher (р = 0,0498) in patients from the І group (109,7 ± 3,21) g/m2 comparable with the ІІ (97,6 ± 5,35) g/m2 and increased in proportion to the biggest level of uric acid (r = 0,31; p = 0,04) in patients with arterial hypertension and hyperuricemia. Conclusions: Concentric and excentric left ventricular hypertrophy, increased left ventricular mass index proportionally to uric acid levels (r = 0,31; p = 0,04) is the confirmation of important role of hyperuricemia in the left ventricular hypertrophy development in patients with arterial hypertension.

Aim: The study aimed to develop an algorithm for organizing the work of a multidisciplinary palliative care team in a territorial community. Materials and Methods: The following methods were employed: analysis of the regulatory framework, statistical data, international and domestic experience, scientific literature, opinion survey, strategic sessions, participant observation. The field research was conducted by the Center for Social Research of Sumy State University together with the NGO “Family Circle of Trostianechchyna (Trostianets district)” in the Trostianets territorial community of Sumy region (Ukraine) during September-October 2021. Eighty respondents took part in the survey. Up to 30 people joined the strategic sessions at different stages. Results: The survey discovered that at the research time in the pilot territorial community, the needs of palliative patients were more restrained than those who rendered assistance. However, in both cases, there is a high demand for social services against the background of medical services. Proceeding from the identified needs and by the results of strategic sessions, we proposed an algorithm for organizing the work of a multidisciplinary palliative care team at the territorial community level. The algorithm distinguishes between the program and operational levels. We put forward the structure of the interdisciplinary palliative care team. Conclusions: As a conclusion, we can specify the following points. The study confirmed the hypotheses that the basics of the identified needs and the use of strategic sessions with multidisciplinary participation of community members facilitate the development of an efficient algorithm. The designed operational level of the interdisciplinary team recorded the practices available in the pilot community. Simultaneously, the collaborative design determined the development of the multidisciplinary team itself. The involvement of management representatives, junior medical staff, and social workers became an essential factor in their inspiration, contributing to the development of human resources for a new level of quality in palliative care.

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The aim of the study was to find dependence of left ventricular hypertrophy indexes to polymorphism of Les198Asn gene endothelin-1 and BMI. Materials and methods: We took research in 160 patients with arterial hypertension, using ECG and polymerase chain reaction (PCR). Groups were divided additionally according to BMI (body mass index). Results: It was found, that patients with obesity had their Left ventricular mass and hypertrophy left ventricular indexes higher, than in patients with normal and increased body weight. Carriers of Asn198Asn and Lys198Asn genotypes Left ventricular mass and hypertrophy left ventricular indexes are higher than in carriers of Lys198Lys genotype. Conclusions: It was determined that in patients-carriers of Asn198Asn genotype, Left ventricular mass (LVMI) and hypertrophy left ventricular indexes (LVMMI) were higher compared to patients-carriers of Lys198Lys and Lys198Asn type, both in men and women. The dependence of LVMI and LVMMI are shown to be higher in patients with obesity than in people with normal and increased body mass.

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