Two types of gold nanoparticles, covered with SiO 2 shell and located on the SiO 2 large nanoparticle-carrier, have been synthesized and used as antiviral agents against adenoviruses. Both antiviral effect and virucidal action of the nanoparticles have been studied. It has been shown that both types of nanoparticles demonstrate antiviral action. Dependence of antiviral activity of nanoparticles on their concentration has been studied. Nonmonotonic dependence of the antiviral effect on nanoparticles concentration has been observed and discussed. The antiviral action of complex nanoparticles against adenovirus is important because of low toxicity of the gold nanoparticles covered with SiO 2 shell and of Au-SiO 2 carrier nanoparticles.
Nano-hydroxyapatite and its modification, hydroxyapatite with the
excess of phosphorus (P-HAP) and hydroxyapatite with the carbon ions built into the
structure (C-HAP), were prepared by the wet method. They were studied by means of
XRD, accelerated surface area and porosimetry (ASAP), and SEM. The size of
crystallites computed using the Scherrer method was nano-hydroxyapatite
(HAP) = 20 nm; P-HAP—impossible to determine; C-HAP = 22 nm;
nano-HAP/U(VI) = 13.7 nm; P-HAP/U(VI)—impossible to determine, C-HAP/U(VI) = 11 nm.
There were determined basic parameters characterizing the double electrical layer at
the nano-HAP/electrolyte and P-HAP/electrolyte, C-HAP/electrolyte inter faces:
density of the surface charge and zeta potential. The adsorption properties of
nano-HAP sorbent in relation to U(VI) ions were studied by the batch technique. The
adsorption processes were rapid in the first 60 min and reached the equilibrium
within approximately 120 min (for P-HAP) and 300 min (for C-HAP and nano-HAP). The
adsorption process fitted well with the pseudo-second-order kinetics. The
Freundlich, Langmuir–Freundlich, and Dubinin–Radushkevich models of isotherms were
examined for their ability to the equilibrium sorption data. The maximum adsorption
capabilities (q
m) were 7.75 g/g for P-HAP, 1.77 g/g for C-HAP, and 0.8 g/g for HAP at
293 K.
Electrostatic stabilization is reduced in its efficiency in an electrolyte-containing environment. The effect of electrolyte concentration is mostly described as negative factor for dispersion stabilization. Usually, zeta potential and physical stability decrease at increasing electrolyte concentration. The purpose of the present study was to measure the surface properties of nanotubes in aqueous solution of monovalent electrolytes at different concentration. Characteristics such as size distribution, surface chemistry, surface charge, and dispersability in aqueous phase have been identified. Hydrodynamic size and zeta potential in aqueous multiwalled carbon nanotube (MWCNT) suspensions were determined at different pH with the desired concentrations of electrolyte of the cationic group (NaCl, KCl, CsCl) and the anionic group (NaClO4). The correlations between the response of the surface functionality of pristine and oxidized multiwalled carbon nanotubes and electrical double layer (EDL) forming at different ionic environments in the vicinity of a nanotube surface were determined. The nanotube dispersion stabilization was found to be more affected by ion size and pH medium then electrolyte concentration. The data obtained confirms the predominant role of surface reactions. The most stable dispersion of nanotubes was achieved in KCl electrolyte solution at less negative charge of the surface.
The release profiles of acidic form of diclofenac sodium adsorbed on mesoporous silicas (Silochrom and two samples of spherical silicas) were compared with the dissolution characteristics of the pure drug. Desorption of diclofenac sodium from impregnated silicas with various surface liophilicity and composites of silica with chitosan have been studied using rotating basket method in phosphate buffer, pH 6.8. Sedimentations of sodium diclofenac via adsorption and impregnation from alcohol solution on fumed silica and modified silicas with grafted aminopropyl and trimethylsilyl groups were carried out. Polymer-containing composites have been prepared by capsulation of silica particles with impregnated diclofenac sodium by protonated and deprotonated forms of chitosan. Effect of the silica surface nature on the active substance release rate was ascertained. Significant prolongation of diclofenac sodium release was detected in the case of application of hydrophobic silica as a carrier and protonated chitosan as a polymeric shell.
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