Aims: Due to a large number of identified hub-genes, encoding key molecular regulators, which involve in signal transduction and metabolic pathways in cancers, it is relevant to systemize and update these findings. Background: Colorectal cancer (CRC) is the third leading cause of cancer death in the world with high metastatic potential. Elucidating the pathogenic mechanisms and selection of novel biomarkers in CRC is of great clinical significance. Objective: This analytical review aims at systematization of bioinformatics and experimental identification of hub-genes, associated with CRC, for a more consolidated understanding of common features in networks and pathways in CRC progression as well as hub-genes selection. Results: In total, 301 hub-genes were derived from 40 articles. The “core” consisted of 28 hub-genes (CCNB1, LPAR1, BGN, CXCL3, COL1A2, UBE2C, NMU, COL1A1, CXCL2, CXCL11, CDK1, TOP2A, AURKA, SST, CXCL5, MMP3, CCND1, TIMP1, CXCL8, CXCL1, CXCL12, MYC, CCNA2, GCG, GUCA2A, PAICS, PYY and THBS2) mentioned in not less than three articles and having clinical significance in cancer-associated pathways. Of them, there were two discrete clusters enriched in chemokine signaling and cell cycle regulation genes. High expression levels of BGN and TIMP1 and low expression levels of CCNB1, CXCL3, CXCL2, CXCL2 and PAICS were associated with unfavorable overall survival of patients with CRC. Differently expressed genes such as LPAR1, SST, CXCL12, GUCA2A, and PYY were shown as down regulated, whereas BGN, CXCL3, UBE2C, NMU, CXCL11, CDK1, TOP2A, AURKA, MMP3, CCND1, CXCL1, MYC, CCNA2, PAICS were up regulated genes in CRC. It was also found that MMP3, THBS2, TIMP1 and CXCL12 genes were associated with metastatic CRC. Network analysis in ONCO.IO showed that upstream master regulators RELA, STAT3, SOX2, FOXM1, SMAD3 and NF-kB were connected with “core” hub-genes. Conclusion: Results obtained are of useful fundamental information on revealing mechanism of pathogenicity, cellular targets selection for optimization of therapeutic interventions as well as transcriptomics prognostic and predictive biomarkers development.
In the context of the Ukrainian crisis, the Law ‘On the specifics of state policy to ensure the state sovereignty of Ukraine in the temporarily occupied territories in Donetsk and Lugansk regions’, which is also called the ‘Law on De-occupation (or Reintegration) of Donbas’, became the key point. After four years of occupation of parts of southeastern Ukraine, the adoption of such a law was necessary, since this particular law formed and legally established the legal and organizational conditions for the resumption of territorial integrity of Ukraine. The importance of this law and the consequences of its adoption caused public involvement on behalf of civic organizations, political analysts, representatives of the academic and economic elite in the process of its discussion. However, due to the small amount of time from the stage of the legislative initiative to the publication of the law, it was not officially discussed by the public. Despite this, the enactment of the law led to an active public debate. Our study is aimed to investigate the degree of public involvement in the political decision-making process and the extent of public influence on lawmaking in Ukraine on the example of this legislative act.
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