In this work, the defective Cu-BDC with different defect concentration and Cu1+/Cu2+ coordinatively unsaturated sites (CUS) content were designed and synthesized by introducing defective linkers with different pKa values. The...
Nitrofuran
(NF) is a class of broad-spectrum antibiotics that are
used illegally in animal feeding. NF and its metabolites have proven
to pose potential risk to human health. To address the current analytical
needs to quantify low levels of NF metabolites in animal foods, a
sensitive method was developed for simultaneous detection of four
NF metabolites in fish products by an ultraperformance liquid chromatography-diode
array detector (UPLC-DAD). With 2-nitrobenzaldehyde (2-NBA) as the
derivatizing reagent, the metabolites were hydrolyzed and derivatized
under the assistance of thermostatic ultrasound. Compared with the
current detection methods, the time of the derivatization reaction
has been shortened from 16 to 2 h. The relative coefficient of four
NF metabolite derivatives reached more than 0.998, with excellent
linear relationship. The limits of detection (LODs) and limits of
quantification (LOQs) of six repeated determinations reached 0.25–0.33
and 0.80–1.10 μg/kg, respectively. For all four NF metabolites,
the limit of detection of the method was below the minimum required
performance limit (MRPL) of 1.0 μg/kg, which makes it compatible
with the EU requirements. The recoveries ranging from 89.8 to 101.9%
with relative standard deviation below 6.5% were obtained for all
of the NF metabolites. What’s more, this method was successfully
applied for the determination of four NF metabolites in the fish products.
As a promising approach, this method could also be extended for the
quantitation of NF metabolites in aquaculture and poultry products.
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