No abstract

1,1-Diphenyl- and 1,1-dimethylsilacyclobutanes reacted with Me2Pd(dmpe) (dmpe = 1,2-bis(dimethylphosphino)ethane) or Pd(PhCHCH2)(dmpe) to give 2,2-diphenyl- and 2,2-dimethyl-1-pallada-2-silacyclopentane complexes, the diphenyl complex being characterized by X-ray analysis. Treatment of the diphenyl complex with acetylenes or 1,2-disilacyclopentane induced reductive elimination to regenerate the parent 1,1-diphenylsilacyclobutane. A dihydrosilane or a silacyclobutane reacted with the diphenyl complex to afford a 1,3-bis(hydrosilyl)propane or a 1,5-disilacyclooctane, respectively.

The photo-generated closed-ring isomer of bis(5-methyl-2-phenylthiazoyl)perfluorocyclopentene shows cytotoxicity to Madin-Darby canine kidney (MDCK) cells through a caspase cascade and induces apoptosis of cells.

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The clinical features and outcome of small intestinal lymphoma remain unclear. We retrospectively analyzed 23 patients who had non-Hodgkin lymphoma with a small intestinal lesion. With a median follow-up of 37 months, the 5-year overall survival and failure-free survival (FFS) were 64% and 60%, respectively. In a univariate analysis, a worse performance status at the start of treatment and the occurrence of abdominal symptoms or perforation during treatment were associated with poor survival. Perforation often resulted in a dismal prognosis in patients with uncontrollable lymphoma, but not in patients with lymphoma in remission. The role of surgery in small intestinal lymphoma remains equivocal. In the current study, surgery before other therapies favorably influenced FFS, and all patients who underwent complete resection of the small intestinal lesion had extremely favorable results. Further studies are warranted to establish optimal therapeutic strategies.

No abstract

Palladium and platinum complexes catalyze the reaction of silacyclobutanes with acid chlorides in the presence of a large excess of a tertiary amine (triethylamine, diisopropylethylamine) at higher temperatures (∼80 °C) to give cyclic silyl enol ethers, 1-sila-2-oxa-3-cyclohexenes, in excellent yields, while the reaction in the presence of a limited quantity of the amine at room temperature forms 3-(chlorosilyl)propyl ketones in good yields.

Objective: The aim of this study was to identify clinical features and virological aspects of infectious sources that are related to the severity of sexually transmitted acute hepatitis B virus (HBV) infection in patients, especially in cases of genotype C. Methods: Nineteen patients with acute HBV infection, 10 classified with severe acute hepatitis (SH) (prothrombin time; PT <40%) and 9 with typical acute hepatitis (AH) (PT >40%), and their infectious sources (all were sexual partners) were studied. Infectious source factors were analyzed in relation to the severity of hepatitis in the patients’ partners. Results: The nucleotide homology of HBV-DNA between each pair was ≧98.9%. Sixteen were infected with HBV genotype C. Among the 16 infectious sources, age, numbers with elevated alanine aminotransferase (ALT, 7/9 vs. 1/7), anti-HBe positivity (8/9 vs. 1/7) and core promoter mutations at nt 1762 (7/9 vs. 1/7), nt 1764 (8/9 vs. 1/7) and precore mutation at nt 1896 (8/9 vs. 1/7) were significantly higher in the sources of SH than in those of AH. Conclusion: Higher age, elevated ALT, anti-HBe positivity and core promoter/precore mutations were possible risk factors for an infectious source of the severe form of sexually transmitted acute hepatitis due to HBV genotype C.