To clarify the association of clinical and prognostic features with dermatomyositis (DM)specific autoantibodies (Abs) in adult Japanese patients with DM.

(18)F-FDG PET is considered to be useful for the diagnosis and evaluation of disease activity along with HRCT findings, and in monitoring response to chemotherapy in patients with PM.

The purpose of this study was to delineate the differences in intratumoral uptake and tracer distribution of 62 Cu-diacetylbis(N 4 -methylthiosemicarbazone) ( 62 Cu-ATSM), a well-known hypoxic imaging tracer, and 18 F-FDG in patients with lung cancer of pathohistologically different types. Methods: Eight patients with squamous cell carcinoma (SCC) and 5 with adenocarcinoma underwent 62 Cu-ATSM and 18 F-FDG PET within a 1-wk interval. For 62 Cu-ATSM PET, 10-min static data acquisition was started at 10 min after a 370-to 740-MBq tracer injection. After image reconstruction, 62 Cu-ATSM and 18 F-FDG images were coregistered, and multiple small regions of interest were drawn on tumor lesions of the 2 images to obtain standardized uptake values (SUVs). The regression lines were determined between SUVs for 62 Cu-ATSM and 18 F-FDG in each tumor. The slope values were compared between SCC and adenocarcinoma to observe pathohistologic differences in intratumoral distribution of the tracers. Results: SUVs for 62 Cu-ATSM were lower than those for 18 F-FDG in both SCC and adenocarcinoma. SCC tumors showed high 62 Cu-ATSM and low 18 F-FDG uptakes in the peripheral region of tumors but low 62 Cu-ATSM and high 18 F-FDG uptakes toward the center (spatial mismatching). The relationship of SUVs for the 2 tracers was negatively correlated with a mean regression slope of 20.07 6 0.05. On the other hand, adenocarcinoma tumors had a spatially similar distribution of 62 Cu-ATSM and 18 F-FDG, with positive regression slopes averaging 0.24 6 0.13. The regression slopes for 62 Cu-ATSM and 18 F-FDG differed significantly between SCC and adenocarcinoma (P , 0.001). Conclusion: The intratumoral distribution patterns of 62 Cu-ATSM and 18 F-FDG were different between SCC and adenocarcinoma in lung cancers, indicating that intratumoral regions of high glucose metabolism and hypoxia could differ with the pathohistologic type of lung cancer. The identification of regional biologic characteristics in tumors such as hypoxia, energy metabolism, and proliferation could play a significant role in the clinical diagnosis and therapy planning for non-small cell lung cancer patients.

No abstract

Early SUV and RI-SUV obtained from dual-time-point (18)F-FDG PET are useful parameters for the differential diagnosis and prediction of disease progression in patients with IIP.