Detection
of adverse effects of cardiac toxicity at an early stage
by in vitro methods is crucial for the preclinical drug screening.
Over the years, several kinds of biosensing platforms have been proposed
by the scientific society for the detection of cardiac toxicity. However,
the proposed tissue platforms have been optimized to measure either
mechanophysiology or electrophysiology of the cardiomyocytes but not
both. Herein, we demonstrate in detail our successful attempt toward
developing a novel “multifunctional microphysiological system”
also known as “organs-on-chips” to measure simultaneously
the mechanical and electrical characteristics of cardiomyocytes in
vitro. The proposed device can rapidly recognize drug-induced cardiovascular
toxicity in real time, which is one of the most significant factors
for drug discovery and postmarketing surveillance. We confirm that
the proposed sensor delivers the direct relationship between the contraction
force and cell impedance of cardiomyocytes under the influence of
different cardiovascular drugs such as verapamil, astemizole, and
lidocaine. The obtained assay results provide a great potential for
a deep understanding of the drug effects on the cardiomyocytes in
vitro.
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