Objective: To test the efficacy of topical treatment with gentian violet on methicillin-resistant Staphylococcus aureus (MRSA). Study Design: Retrospective study.Setting: Territorial referral centre.Patients: Patients with discharging ears infected with MRSA alone or MRSA and Pseudomonas aeruginosa (PA). Intervention: One percent gentian violet was applied.Main Outcome: Remission of discharge. Results: Remission was obtained in 44 of 46 ears infected with MRSA, whereas remission was obtained in only 3 of 6 ears infected with MRSA and PA. The minimum inhibitory concentrations (MICs) of gentian violet for MRSA strains sensitive to topical application of gentian violet and strains resistant to this treatment were 0.03 ^g/mL and 0.5%, respectively. The MIC for PA resistant to topical gentian violet treatment was higher than 32 (ig/mL Conclusions: Topical application of gentian violet is a useful option for the treatment of refractory discharging ears infected with MRSA. However, great care must be taken if there is any chance of the gentian violet reaching the middle ear. SOMMAIRE Objectif: Tester I'efficacite du violet de gentian pour traiter le Staphylocoque dore resistant a la methicilline (SARM) Dews.' Etude retrospectiveLocalisation: Centre de reference territorial. Patients: Patients avec otorrhee infectee par le SARM seul ou le SARM avec Pseudomonas Aeruginosa (PA). Intervention: Application de violet de gentian a 1%Variable evaluee: Correction de I'otorrhee. Resultats: Nous avons obtenu un arret de I'otorrhee chez 44 des 46 oreilles infectees par le SARM mais seulement 3 sur 6 infectees par le SARM et le Pseudomonas. La concentration minimale inhibltrice du violet de gentian pour les souches sensibles et resistantes au traitement etait de 0.03 |jg/ml et de 0.5% respectivement. Dans le cas des pseudomonas resistants, la CMI etait de 32 )ig/ml. Conclusion: L'application topique de violet de gentian est une option utile dans le traitement de I'otorrhee refractaire causee par le SARM. II faut bien sur toujours etre prudent s'il y a une chance que le violet de gentian atteigne I'oreille moyenne.
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