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A hydroponics experiment was conducted to investigate the effect of copper (Cu) on cadmium (Cd), calcium (Ca), iron (Fe), and zinc (Zn) uptake by several rice genotypes. The experiment was carried out as a 2×2×4 factorial with four rice genotypes and two levels of Cu and Cd in nutrient solution. Plants were grown in a growth chamber with controlled environment. The results showed a significant difference between the biomass of different rice genotypes (P < 0.001). The Cd and Cu concentration in the solution had no significant effect on the biomass. The addition of Cu significantly decreased Cd uptake by shoots and roots of rice (P < 0.001). The Cd concentration did not significantly influence Ca uptake by plants, whereas the Cu concentration did (P = 0.034). There was a significant influence of Cd on Fe uptake by shoots and roots (P < 0.001, P = 0.003, respectively). Zn uptake decreased significantly as the addition of Cd and Cu increased in shoots. We concluded that Cu had significant influence on Cd uptake. The possible mechanisms were discussed.