The currently available clinical tools have limited accuracy in predicting hip fracture risk in individuals. We investigated the possibility of using normalized cortical bone thickness (NCBT) estimated from the patient's hip DXA (dual energy X-ray absorptiometry) as an alternative predictor of hip fracture risk. Hip fracture risk index (HFRI) derived from subject-specific DXA-based finite element model was used as a guideline in constructing the mathematical expression of NCBT. We hypothesized that if NCBT has stronger correlations with HFRI than the single risk factors such as areal BMD (aBMD), then NCBT can be a better predictor. The hypothesis was studied using 210 clinical cases, including 60 hip fracture cases, obtained from the Manitoba Bone Mineral Density Database. The results showed that, in general HFRI has much stronger correlations with NCBT than any of the single risk factors; the strongest correlation was observed at the superior side of the narrowest femoral neck with r2 = 0.81 (p < 0.001), which is much higher than the correlation with femoral aBMD, r2 = 0.50 (p < 0.001). The capability of aBMD, NCBT, and HFRI in discriminating the hip fracture cases from the non-fracture ones, expressed as the area under the curve with 95% confidence interval, AUC (95% CI), is respectively 0.627 (0.593–0.657), 0.714 (0.644–0.784) and 0.839 (0.787–0.892). The short-term repeatability of aBMD, NCBT, and HFRI, measured by the coefficient of variation (CV, %), was found to be in the range of (0.64–1.22), (1.93–3.41), (3.10–4.16), respectively. We thus concluded that NCBT is potentially a better predictor of hip fracture risk.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.