(E)-O-Propargylic arylaldoximes were regioselectively converted, in the presence of copper catalysts, into their corresponding four-membered cyclic nitrones in good to excellent yields. The reactions proceeded via a tandem [2,3]-rearrangement and 4π-electrocyclization of the N-allenylnitrone intermediate and involved cleavage of the carbon-oxygen bond.
Highlights d LN211E8 promotes hiPSC differentiation into neural crest cells via Wnt activation d LN332E8 promotes hiPSC differentiation into corneal epithelial cells d LN511E8 led to YAP inactivation and retinal differentiation in hiPSC colony centers d Distributions of laminins in the developmental eye mirrored the hiPSC type it induced
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