Respiratory impairment due to damage of the spinal respiratory motoneurons and interruption of the descending drives from brainstem premotor neurons to spinal respiratory motoneurons is the leading cause of morbidity and mortality following cervical spinal cord injury. The present study was designed to evaluate the therapeutic effectiveness of delayed transplantation of fetal spinal cord (FSC) tissue on respiratory function in rats with mid-cervical spinal cord injury. Embryonic day-14 rat FSC tissue was transplanted into a C4 spinal cord hemilesion cavity in adult male rats at 1 week postinjury. The histological results showed that FSC-derived grafts can survive, fill the lesion cavity, and differentiate into neurons and astrocytes at 8 weeks post-transplantation. Some FSC-derived graft neurons exhibited specific neurochemical markers of neurotransmitter (e.g., serotonin, noradrenalin, or acetylcholine). Moreover, a robust expression of glutamatergic and γ-aminobutyric acid-ergic fibers was observed within FSC-derived grafts. Retrograde tracing results indicated that there was a connection between FSC-derived grafts and host phrenic nucleus. Neurophysiological recording of the phrenic nerve demonstrated that phrenic burst amplitude ipsilateral to the lesion was significantly greater in injured animals that received FSC transplantation than in those that received buffer transplantation under high respiratory drives. These results suggest that delayed FSC transplantation may have the potential to repair the injured spinal cord and promote respiratory functional recovery after mid-cervical spinal cord injury.
In recent years, children’s use of mobile phones has grown rapidly, which might lead to an increase in mental stress and negatively affect their health. Despite increasing evidence that horticultural activity can provide significant health benefits, few scientific evidence-based studies are currently available regarding these benefits to children’s health and wellbeing in schools. Therefore, this study aims to determine the potential benefits of horticultural activity for children from both psychological and physiological perspectives. Twenty-six elementary school students (mean age, 8.12 ± 0.21 years) were asked to perform a plant-related task and a mobile game task for 5 min. During both tasks, physiological sensors were used to measure the participants’ heart rate variability, skin conductance, and skin temperature. Additionally, the participants’ emotional responses were assessed using semantic differential and State–Trait Anxiety Inventory tests immediately after each task. Results revealed that, compared with the mobile game task, participants’ health statuses were positively correlated with the horticultural task, including a considerable decrease in skin conductance and sympathetic nervous activity, together with a marginal increase in parasympathetic nervous activity. Such responses suggested that horticultural activity increased relaxation and decreased feelings of stress. Furthermore, the horticultural activity was associated with a substantial increment in comfort, naturalness, relaxation, and cheerfulness feelings, as well as a significant reduction in depression and a reduction in total anxiety levels. Given these positive benefits, horticultural activity may provide a great contribution to children’s healthy life at school, prompt psychological relaxation and minimize mental stress relative to smartphone games.
The importance of multi-sensory perception in constructing human landscape experiences has been increasingly emphasized in contemporary urban life. The aim of this study is to explore aural-visual interaction attributes that may influence people’s perceived overall soundscape comfort in urban green spaces (UGSs). To achieve this, a total of 12 perceptive indicators were identified from the existing literature to evaluate people’s perceived visual and acoustic attributes and types of sound sources, and their relations to the perceived soundscape comfort. 268 responses were obtained in a questionnaire-based survey conducted in five UGSs in Chengdu Outer Ring Ecological Zone. This was done whilst a typical objective acoustic indicator, sound level, was used as a mediator for potential changes on these relations within different sound level ranges. Results suggested that a low level of environmental sound does not correspond to higher ratings on the overall soundscape comfort. It was also found that the environmental sound level of 77 dBA was a turning point in the relation between people’s soundscape comfort and its influential indicators in UGSs. A set of six models was then provided to describe the overall soundscape comfort and its contributing indicators in aural-visual interactions, respectively, in sound level ranges below and above 77dBA.
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